Results 161 to 170 of about 2,635,983 (189)

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

open access: yesAdvanced Science, EarlyView.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti   +3 more
wiley   +1 more source

Identification of a Homozygous Variant in the <i>CYP21A2</i> Gene by Next-Generation Sequencing Analysis of Circulating Cell-Free Fetal DNA. [PDF]

open access: yesGenes (Basel)
Petrillo N   +13 more
europepmc   +1 more source

A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma

open access: yesAdvanced Science, EarlyView.
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye   +21 more
wiley   +1 more source

Adaptive Catalytic Nanointerfaces for Controlled Hydrogen Evolution: an in Situ Electrochemical Approach

open access: yesAdvanced Science, EarlyView.
The ability to switch the HER activity of precious metals at will through a reconfigurable step‐edge/nanoparticle interface, using sulfur as an inorganic mediator, is demonstrated for the first time. This methodology addresses the durability issue of highly catalytic precious metals, which are typically single‐use, thereby extending their lifespan ...
Carlos Herreros‐Lucas   +6 more
wiley   +1 more source

The impact of the COVID-19 pandemic on ST-segment elevation myocardial infarction treatment strategy and outcomes. [PDF]

open access: yesFront Cardiovasc Med
Bychowski J   +4 more
europepmc   +1 more source

A Review of Ga₂O₃ Heterojunctions for Deep‐UV Photodetection: Current Progress, Methodologies, and Challenges

open access: yesAdvanced Electronic Materials, EarlyView.
This paper provides a comprehensive review of the existing literature related to the fundamentals of gallium oxide (Ga2O3), growth methods, substrates, and particularly a focused examination of Ga2O3‐based heterojunctions. Particular attention has also been given to the state‐of‐the‐art Ga2O3‐based heterojunctions for photodetectors. The key challenges
Alfred Moore   +4 more
wiley   +1 more source

Neural‐Network Potential for Defect Formation Induced by Knock‐On Irradiation Damage in 4H‐SiC

open access: yesAdvanced Electronic Materials, EarlyView.
This study constructed an efficient neural network potential (NNP) for simulating the irradiation damage in 4H‐SiC with accuracy at first‐principles level. Using this NNP, the directional dependence of the threshold displacement energies (TDE) is determined based on high‐throughput calculations, and the calculated minimal TDE agrees with experiments ...
Wei Liu   +4 more
wiley   +1 more source

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