Results 301 to 310 of about 1,368,154 (362)

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

Novel single-cell preservation and RNA sequencing technology unlocks field studies for Plasmodium natural infections. [PDF]

Sci Rep
Sauve E, Monsieurs P, Guetens P, de Moraes Barros RR, Rosanas-Urgell A.   +4 more
europepmc   +1 more source

AIRBORNE GRAVITY GRADIOMETRY SURVEY IN THE SOUTHEASTERN PORTION OF PIMENTA BUENO GRABEN IN PARECIS BASIN: INTEGRATED 2D FORWARD MODELING AND ITS IMPLICATIONS IN DEFINING A NEW STRUCTURAL FRAMEWORK

, 2015
Alan de Souza Cunha, Fábio André Perosi, Luiz F. S. Braga, Leandro B. Adriano, Marlon C. Hidalgo-Gato, Victor Pereira do Couto, Daniel S. da Silva   +6 more
openalex   +2 more sources

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Author Correction: A constellation of mud volcanoes originated from a buried Arctic mega-slide, Southwestern Barents Sea. [PDF]

Sci Rep
Argentino C, Mattingsdal R, Eidvin T, Ohm SE, Panieri G.   +4 more
europepmc   +1 more source

Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases

Advanced Science, EarlyView.
We present a functional three‐dimensional in‐vivo‐mimicking human colon (3D‐IVM‐HC) model engineered via Freeform Reversible Embedding of Suspended Hydrogels bioprinting with gelatin methacrylate (GelMA)/alginate hydrogels. This 3D non‐animal model replicates crypt‐like architectures, epithelial polarization, and stromal–tumor interactions, showing ...
Jorge Alfonso Tavares‐Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour   +7 more
wiley   +1 more source

Modeling of potential field data for detecting structural and tectonic framework of Esh El Mellaha area, Red Sea, Egypt. [PDF]

Sci Rep
Abudeif AM, Hamimi Z, Gaber GM, Kotb A, Alarifi N, Bellucci S, Masoud MM.   +6 more
europepmc   +1 more source

Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition

Advanced Science, EarlyView.
This review summarizes the current landscape of big data and AI‐powered modeling in animal nutrition, covering techniques including intelligent data acquisition, data augmentation, explainable machine learning, heuristic algorithms, and life cycle assessment‐based sustainability evaluation.
Shuai Zhang, Changhua Lai, Jinbiao Zhao, Junjun Wang   +3 more
wiley   +1 more source

Metabolite accumulation contributes to differences in seed germination of water-saving and drought-resistance rice under dry direct seeding. [PDF]

BMC Plant Biol
Fu Y, Zheng G, Ma L, Li J, Hou D, Zhang L, Zeng B, Bi Q, Tan J, Yu X, Bi J, Luo L.   +11 more
europepmc   +1 more source

Bioinspired Twisted Artificial Muscles with Enhanced Performance for Underwater Applications

Advanced Science, EarlyView.
A climbing plant‐inspired twisted artificial muscle (TAM) with a braided configuration and seal‐inspired thermal insulation enables high‐performance underwater actuation. Enhanced deformation, reduced heat dissipation, and rapid motion are validated through a bionic ray that exhibits straight and turning motions.
Jin Sun, Yuan Fu, Shijng Zhang, Jing Li, Dehong Wang, Junkao Liu, Yingxiang Liu   +6 more
wiley   +1 more source