Results 101 to 110 of about 123,501 (158)

Cyclocondensation of 2-(α-Diazoacyl)-2H-azirines with Amidines in Diazo Synthesis of Functionalized Naphtho[1,2-d]imidazoles.

Journal of Organic Chemistry
A diazo approach toward functionalized naphtho[1,2-d]imidazole derivatives has been developed. It involved a new reaction of arylamidines with 2-(α-diazoacyl)-2H-azirines giving 5-aryl-4-(α-diazoacyl)-1H-imidazoles under mild conditions in good yields ...
Timur O Zanakhov, E. Galenko, M. Novikov, A. Khlebnikov   +3 more
semanticscholar   +1 more source

Switchable Assembly of Substituted Pyrimidines and 2H-imidazoles via Cu(I)-catalysed Ring Expansion of 2-Meoxyl-2H-azirines

Organic Chemistry Frontiers, 2022
The unprecedented switchable synthesis of substituted pyrimidines and 2H-imidazoles via Cu(I)-catalyzed ring expansion of 2-meoxyl-2H-azirines is described. This protocol features broad substrate scope and allows rapid assembly of amides.
Shaofa Sun, Jie Huang, C. Yuan*, Gangqiang Wang, Donghui Guo, Jian Wang   +5 more
semanticscholar   +1 more source

Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNA.

European journal of medicinal chemistry, 2021
Multiple-target drugs may achieve better therapeutic effect via different pathways than single-target ones, especially for complex diseases. Tubulin and DNA are well-characterized molecular targets for anti-cancer drug development.
Shibo Lin, Yu-Ru Liang, Jiayi Cheng, Feng Pan, Yang Wang   +4 more
semanticscholar   +1 more source

Conical intersections and photoreactions of 2H-azirines

Chemical Physics, 2000
Abstract CASSCF calculations were performed on the nπ * - and ππ * -excited states of 2 H -azirine as well as some alkyl-substituted 2 H -azirines. An S 1 /S 0 conical intersection (CI) was located, through which a direct formation of nitrile ylide can occur.
Christian Bornemann, Martin Klessinger
openaire   +1 more source

Synthesis of oxaprozin analogs from 2H-azirines and cyclic anhydrides

Organic & Biomolecular Chemistry
We report a novel, transition-metal- and base-free cascade reaction between 2H-azirines and cyclic anhydrides, yielding oxaprozin analogs containing a trisubstituted oxazole core through a ring-opening and annulation sequence.
Rayhaneh Azimi, K. Amiri, S. S. Hosseini, Rob Stranger, Alireza Ariafard, F. Rominger, H. Bijanzadeh, S. Balalaie   +7 more
semanticscholar   +1 more source

Synthesis of functionalized 1-aminoisoquinolines through cascade three-component reaction of ortho-alkynylbenzaldoximes, 2H-azirines, and electrophiles.

Organic and biomolecular chemistry, 2022
We have developed a new three-component approach using ortho-alkynylbenzaldoximes involving the formation of a cyclic nitrone in the presence of Br2 or ICl for the synthesis of 1-aminoisoquinolines via cascade 6-endo-cyclization, 1,3-dipolar ...
Reyhaneh Hosseinijei, Hossein Zahedian Tejeneki, Ali Nikbakht, F. Rominger, S. Balalaie   +4 more
semanticscholar   +1 more source

Thermal rearrangements of 2,3-diphenyl-2H-azirine

Journal of the Chemical Society, Perkin Transactions 1, 1973
Heating 2,3-diphenyl-2H-azirine in a sealed tube at 250 °C for 3 h yields 2-phenylindole, 2,3,4,5-tetraphenylpyrrole, 2,4,5-triphenylimidazole, and 1-benzyl-2,4,5-triphenylimidazole as major products, with tetraphenylpyrazine, tetraphenylpyrimidine, pentaphenylpyridine, benzonitrile, benzamide, and stilbene being produced in smaller yield.
John H. Bowie, Brian Nussey
openaire   +1 more source

Rhodium‐Catalyzed (3+3) Cascade Cyclization of Diazobarbiturates with 2H‐Azirines for the Diastereoselective Construction of Spirooxazinopyrimidinediones

Annalen der Pharmacie
Under the catalysis of Rh2(esp)2 (10 mol%) and BINAP (20 mol%) in 1,2‐dichloroethane at 80 °C, a (3+3) cascade cyclization between diazobarbiturates and 2H‐azirines proceeded smoothly, yielding spirooxazinopyrimidinediones in 24‐92% yield with >20:1 ...
Hong‐Wu Zhao, Yue Zhang, Yu-Hang Mi, Kuo Wang, Zhi‐Yu Wang, Jin-Tao Li   +5 more
semanticscholar   +1 more source

Synthesis of Chiral β,β-Disubstituted Ketones via CuH-Catalyzed Coupling of Aryl Alkenes and 3-Aryl-2H-azirines.

Organic Letters, 2022
A CuH-catalyzed coupling of aryl alkenes with 3-aryl-2H-azirines has been developed to synthesize optically active β,β-disubstituted ketones. We propose that this protocol occurs through a sequence in which a chiral alkylcopper complex regioselectively ...
Fang Xie, Shijie Dong, Yajun Sun, Wenxing Liu, Xiaodan Liu, Lu Liu, Qin Zhao, Jiangli Wang   +7 more
semanticscholar   +1 more source

Photocycloaddition reactions of a bis-2H-azirine

Journal of the Chemical Society, Chemical Communications, 1977
Irradiation of 3,3′-(2,2′-biphenylene)bis-(2H)-azirine with electron-deficient dipolarophiles gives cycloadducts derived from a transient azabicyclo[3.1.0]hexene intermediate.
Albert Padwa, Hao Ku
openaire   +1 more source