Results 51 to 60 of about 473,711 (266)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Effective Data-Driven Method for 3-D Building Roof Reconstruction and Robust Change Detection

Remote Sensing, 2018
Three-dimensional (3-D) reconstruction of building roofs can be an essential prerequisite for 3-D building change detection, which is important for detection of informal buildings or extensions and for update of 3-D map database.
Mohammad Awrangjeb, Syed Ali Naqi Gilani, Fasahat Ullah Siddiqui   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

3-D Model Extraction Network Based on RFM-Constrained Deformation Inference and Self-Similar Convolution for Satellite Stereo Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Traditional three-dimensional (3-D) reconstruction methods for satellite stereo images (SSIs) are limited by observation angles and image resolution, resulting in poor reconstruction results and only a rough 3-D model of the extracted target.
Wen Chen, Hao Chen, Shuting Yang
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ancestral Sequence Reconstruction Enhances Thermal Stability of D-Allulose 3-Epimerase

Shipin gongye ke-ji
To solve the problem of poor thermal stability of the current D-allulose 3-epimerase (DAEase), the ancestor sequences of DAEase with different catalytic domains were reconstructed by big data mining, reasonable modification and ancestor sequence ...
Lijun GUAN, Ling ZHU, Kunlun WANG, Jialei LI, Yang GAO, Song YAN, Xindi ZHANG, Qing CHEN, Nina JI, Bo LI   +9 more
doaj   +1 more source

CSR-Net: A Novel Complex-Valued Network for Fast and Precise 3-D Microwave Sparse Reconstruction

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Since the compressed sensing (CS) theory broke through the limitation of the traditional Nyquist sampling theory, it has attracted extensive attention in the field of microwave imaging.
Mou Wang, Shunjun Wei, Jun Shi, Yue Wu, Qizhe Qu, Yuanyuan Zhou, Xiangfeng Zeng, Bokun Tian   +7 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source