Results 91 to 100 of about 4,170,992 (325)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The role of gender in antimicrobial resistance: Findings from a scoping review

Global Public Health
Antimicrobial resistance (AMR) is a growing global health threat requiring a strong focus on equity. This scoping review aimed to document the evidence to outline recommendations for gender-responsive AMR policies, programmes, and interventions aligned ...
Arne Ruckert, Zlatina Dobreva, Suzanne Garkay Naro, Sarah Paulin, Lindsay A. Wilson, Clare McGall, Rosemary Morgan, Mimi (Meheret) Melles-Brewer, Anna Coates, Giada Tu Thanh, Esmita Charani, Amparo Gordillo-Tobar, Deepshikha Batheja, Susan Rogers Van Katwyk   +13 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Additional file 3: of What is a good health check? An interview study of health check providersâ views and practices

, 2017
Comparison of criteria. Comparison between criteria as mentioned by interviewed providers and what is written on these criteria (eg what is mentioned about informed consent) in criteria for responsible population screening and existing criteria for personal health checks (DOCX 114 kb)
Yrrah Stol, Asscher, Eva, Schermer, Maartje   +2 more
openaire   +1 more source

High Autophagy in the Naked Mole Rat may Play a Significant Role in Maintaining Good Health

Cellular Physiology and Biochemistry, 2014
Background/Aims: The maximum lifespan of the naked mole rat is over 28.3 years, which exceeds that of any other rodent species, suggesting that age-related changes in its body composition and functionality are either attenuated or delayed in this ...
Shanmin Zhao, Lifang Lin, Guanghan Kan, Chang Xu, Qiu Tang, Chenlin Yu, Wei Sun, Liping Cai, Chen Xu, Shufang Cui   +9 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Integrated health services for refugee and host populations in Uganda: A qualitative study of stakeholder’s perspectives

Global Public Health
Integration has emerged as a key strategy for promoting equitable access to health services for refugees and host populations. This study explored the perceptions and experiences of stakeholders on the integration of health services for refugees and host
Henry Komakech, Evelyn Baelvina Nyachwo, David Lubogo   +2 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors

BMC Medicine, 2014
In addition to genetic predisposition and sex hormone exposure, physical activity and a healthy diet play important roles in breast cancer (BC). Increased intake of omega-3 fatty acids (n-3) associated with decreased omega-6 (n-6), resulting in a higher ...
M. de Lorgeril, P. Salen
semanticscholar   +1 more source