Results 141 to 150 of about 4,170,992 (325)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Global trends and emerging themes in psychological well‐being and mindfulness research: A science‐mapping study aligned with Sustainable Development Goal 3 (good health and well‐being) [PDF]
Khanh Huy Nguyen, Mai Dong Tran
openalex +1 more source
Global Public HealthThe world’s population is rapidly urbanising, especially in low- to middle-income countries. However, urban living is associated with an increased risk of neurodevelopmental disorders (NDD) like autism spectrum disorders (ASD) and schizophrenia. Exposure
Cole King
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Temporal changes in HIV-related stigma and sexual behaviours: An examination of 22 African countries
Global Public HealthDespite non-trivial success against the HIV epidemic, health experts in Sub-Saharan Africa (SSA) remain concerned about new infections, stigma attitudes, and increasing rates of higher-risk sexual behaviours (HRSBs).
Danielle Denardo, David A. Cort
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
SDG 3: Istanbul Gelisim University Good Health and Well-Being Report: [2019]
, 2023 Contents About the Report Message of the Coordinator Acknowledgement IGU with Figures Social Support Programs Educational Services Smoke-Free Campus ...
openaire +1 more source
Looking for the future – Hope and adolescent risk behaviour in rural KwaZulu-Natal, South Africa
Global Public HealthWe investigate the relationship between hope and risky behaviour and the role of migration among young people in northern KwaZulu-Natal, South Africa.
Faith Magut +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source