Results 191 to 200 of about 4,170,992 (325)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Knowledge and Awareness on Orofacial Clefts Among Healthcare Students: A Cross-Sectional Study. [PDF]

Int J Dent
Rasyid KA, Setiawan AS, Putri FM.
europepmc   +1 more source

Picture Good Health: A Church-Based Self-Management Intervention Among Latino Adults with Diabetes

Journal of general internal medicine, 2015
Arshiya A Baig, Amanda Benitez, C. Locklin, Yue Gao, Sang Mee Lee, M. Quinn, Marla C. Solomon, L. Sanchez-Johnsen, Deborah L. Burnet, M. Chin, Little Village Community Advisory Board   +10 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predicting adherence to fully-automated, chatbot-delivered digital cognitive behavioral therapy for insomnia (dCBT-I) using machine learning: A pilot real-world study. [PDF]

PLOS Digit Health
So RWL, Chan KY, Cheng CCW, Chan NY, Li SX, Chan JWY, Chau SWH, Wing YK, Li TMH.   +8 more
europepmc   +1 more source

“Holistic Healing” – Religion Matters for Good Health and Well-Being (SDG 3)

, 2023
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Influence of health empowerment on health outcomes of different socioeconomic status: evidence from Anhui, China. [PDF]

BMC Public Health
Cheng J, Dai W, Chen S, Wang L, Chen R.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Associations of chronic obstructive pulmonary disease with life satisfaction and self-rated health: quantifying the subjective burden in a population-based study. [PDF]

Qual Life Res
Adebisi YA, Alshahrani NZ, Kalungi G, Somtochukwu OS, Iii Lucero-Prisno DE.   +4 more
europepmc   +1 more source