Results 191 to 200 of about 2,337,820 (261)

Therapist effects in real-world rehabilitation outcomes: a cohort study of the nationwide GLA:D osteoarthritis management programme in Denmark. [PDF]

RMD Open
Obasohan PE, Palmer J, Alderson D, Yu D, Grønne DT, Roos EM, Skou ST, Peat GM.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Feasibility of an App-Based Worksite Health Promotion Program to Improve Mental Well-Being and Work-Related Vitality in University Hospital Workers: Process and Preliminary Effect Evaluation Study. [PDF]

JMIR Form Res
Kremers SHM, Beulens JWJ, Middel CNH, Elders PJM, van der Beek AJ, Rutters F.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of body mass index on dietary habits and health behaviors in breast cancer patients. [PDF]

Front Oncol
Bilska A, Radzimirska-Graczyk M, Popierz-Rydlewska N, Śliwicka E, Liszka M, Nowaczyk P, Siejak W, Gogojewicz A.   +7 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Population expectations of primary care quality in 18 countries: a cross-sectional analysis of data from the People's Voice Survey.

Lancet Prim Care
Lewis TP, Sabwa S, Breda J, Carai S, Clarke-Deelder E, Doubova SV, Fink G, Garcia PJ, Garcia-Elorrio E, Lee HY, Mohan S, Naidoo I, Oh J, Okiro EA, Tadele A, Tarricone R, Ungureanu MI, Wang X, Xu DR, Kruk ME.   +19 more
europepmc   +1 more source

Assessment of Knowledge, Attitudes, and Practices Regarding Microbiota Composition and Influencing Factors Among the Lebanese Population: A Cross-Sectional Study. [PDF]

Cureus
Moukachar A, Khreis I, Tarhini Y, Abou Rached A.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source