YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Exploring the acceptability of engaging in physical activity amongst older adults living in socioeconomically deprived areas after the COVID-19 pandemic: a qualitative study. [PDF]
Harris D +4 more
europepmc +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Community-based mental health interventions for reducing youth suicidal thoughts and behaviours: a systematic review and meta-analysis. [PDF]
Barker L +6 more
europepmc +1 more source
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
The Sociodemographic Risk Factors Associated With Cutaneous Leishmaniasis of the Hazara Community of Quetta, Balochistan, Pakistan: A Cross-Sectional Study. [PDF]
Ali Z +7 more
europepmc +1 more source
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Knowledge of cholera, handwashing practice and its associated factors in Hayayaabe IDP camp, Borama, Somaliland: a community-based study. [PDF]
Hassan MS +7 more
europepmc +1 more source

