Results 231 to 240 of about 4,170,992 (325)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Physical activity and physical activity promotion in Germany - An overview. [PDF]

J Health Monit
Messing S, Birkholz L, Resch J, Brandl J, Lorenz E, Abu-Omar K, Geidl W, Tcymbal A, Gelius P, Pfeifer K.   +9 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Day-to-Day Reproducibility of Arterial Stiffness Following a Bout of Resistance Exercise in Healthy Young Females: A Reliability Study. [PDF]

Health Sci Rep
Blumenburg WT, Soave KM, Currie KD.
europepmc   +1 more source

Aquatic Food Systems and Stunting: A Structured Literature Review of Policy Interventions for SDG 2 (Zero Hunger) and SDG 3 (Good Health and Well-being)

Nico Syahputra Sebayang, Imran Arshad Choudhry   +1 more
openalex   +2 more sources

[SDG 3]: Istanbul Gelisim University Good Health and Well-Being Report: 2024

IGU carries out various initiatives aimed at contributing to the health and well-being of its students, academic and administrative staff, as well as the wider community. These initiatives include the development of innovative educational opportunities and the design of socially impactful projects.
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Evaluating quality of care for dying patients from the perspective of bereaved relatives: validation of the Chinese version of the international care of the dying evaluation. [PDF]

Health Qual Life Outcomes
Zheng X, Zhou L, Li B, Dong L, Li Y, Mayland CR, Aoyama M, Miyashita M.   +7 more
europepmc   +1 more source

Strategic Model for Reducing Stunting Rates Through Parenting Improvement In Indonesia: Supporting SDG 3 to Promote Good Health and Well-Being

Ikeu Kania, Mila Karmila, Ema Rismayanti, Handrini Ardiyanti, Herlina Tarigan, Ni Wayan Supriliyani   +5 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source