Results 251 to 260 of about 8,269,734 (342)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Knowledge and practices regarding infection control precautions against blood-borne diseases among recovered HCV patients in Egypt. [PDF]

Sci Rep
Hussein MF, Hassan WY, Mohamed MH, Mohamed MM, Soliman HMH.   +4 more
europepmc   +1 more source

Aquatic Food Systems and Stunting: A Structured Literature Review of Policy Interventions for SDG 2 (Zero Hunger) and SDG 3 (Good Health and Well-being)

Nico Syahputra Sebayang, Imran Arshad Choudhry   +1 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Feasibility and acceptance of self-applied home type-II PSG studies with a patch-based device. [PDF]

Sleep Breath
Uhles M, Alisic S, Brown A, Doekel R, Booth W, Ojile J.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The relationship between socio-economic and demographic factors, quality of life and depression in older women in institutional care in Poland - a cross-sectional study. [PDF]

BMC Geriatr
Kaczorowska A, Kozieł S, Ignasiak Z.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Assessing Confidence in Adolescent Mental Health Pharmacotherapy in Pediatric Medical Residents. [PDF]

J Pediatr Pharmacol Ther
Summerlin J, Longo E, Baily P, Surendran N, Benavidez V, Raju I, Razmara D, Catanzano S.   +7 more
europepmc   +1 more source

Strategic Model for Reducing Stunting Rates Through Parenting Improvement In Indonesia: Supporting SDG 3 to Promote Good Health and Well-Being

Ikeu Kania, Mila Karmila, Ema Rismayanti, Handrini Ardiyanti, Herlina Tarigan, Ni Wayan Supriliyani   +5 more
openalex   +1 more source