Results 251 to 260 of about 8,467,334 (349)

The Impact of Humour in Digital Ads: A Case Study of Durex Condoms in Achieving SDG-3 (Good Health and Well-Being)

Vebha Shah Dsouza, Archan Mitra
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Self-reported, functional, and objective health and sociodemographic characteristics among older adults in Kenya: findings from the pilot longitudinal study of health and ageing in Kenya (LOSHAK). [PDF]

Front Aging
Mwangi EM, Orwa J, Monchari Riang'a R, Nagarajan N, Agoi F, Mwangala PN, Gross AL, Ikanga JN, Langa KM, Miguel E, Gichu M, Ehrlich JR, Ngugi AK.   +12 more
europepmc   +1 more source

Strategic Model for Reducing Stunting Rates Through Parenting Improvement In Indonesia: Supporting SDG 3 to Promote Good Health and Well-Being

Ikeu Kania, Mila Karmila, Ema Rismayanti, Handrini Ardiyanti, Herlina Tarigan, Ni Wayan Supriliyani   +5 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

COVID-19 Vaccination Knowledge, Attitudes, Perception, and Practices Among Frontline Healthcare Workers in Tunisia, 2024. [PDF]

Vaccines (Basel)
Ben Youssef F, Hechaichi A, Letaief H, Dhaouadi S, Zouaiti A, Talmoudi K, Fitouri S, Fourati A, Mhadhbi R, Sahli A, Nahdi G, Nouira K, Basha I, Bazant E, Griffin C, Palmer K, Alaya NBEB.   +16 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Association of self-rated health and risk of incident atrial fibrillation: Findings from three cohorts. [PDF]

Am J Prev Cardiol
Garg PK, Alam A, Bhatia HS, Horn J, Malmo V, Loennechen JP, Mu S, Foraker R, Selvin E, Janszky I, Heckbert SR, Alonso A.   +11 more
europepmc   +1 more source

Consumer Intention to Purchase Organic Ice Cream: How Health Awareness and Product Knowledge Support SDG 3 on Good Health and Well-Being

Adhi Prakosa, L B Agatha Trie Wulandari, Arif Sudaryana   +2 more
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source