Results 281 to 290 of about 36,543,879 (347)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Association of HIV post-exposure prophylaxis knowledge and utilisation among healthcare workers in Ghana: parallel mediation effect of perceived HIV risk and perceived availability of PEP. [PDF]

BMJ Public Health
Salu PK, Sarfo JO, Amoadu M, Hormenu T.
europepmc   +1 more source

Psychometric evaluation of the Brazilian version of the Postpartum Specific Anxiety Scale - Research Short-Form for Global Crises (PSAS-BR-RSF-C). [PDF]

Arch Womens Ment Health
Gerhardt BC, Zimmer C, Serra J, Souza Torres de Araújo KM, Fallon V, Silverio SA, Xavier Arteche A.   +6 more
europepmc   +1 more source

Sleep Quality and Depressive Symptoms Among Pregnant Women in the Third Trimester: A Cross-Sectional Latent Profile and Network Analysis. [PDF]

Int J Womens Health
Guan Y, Shen Z, Du Q, Tan Q, Tong X.
europepmc   +1 more source

Animal Welfare Assessment in Cattle Breeding in the Natural Savannah of the Colombian Orinoquia. [PDF]

Vet Med Int
Romero MH, Gallego-Polania SA, Sanchez JA, Naranjo-Ramírez JF.   +3 more
europepmc   +1 more source

Relationship of Sleep Quality and Resting Heart Rate with Academic Performance among Preclinical Medical Students at Yobe State University, Damaturu, Nigeria. [PDF]

Niger Med J
Mukhtar IG, Barde AJ.
europepmc   +1 more source