Results 51 to 60 of about 2,098,462 (284)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Analyzing One Health governance and implementation challenges in Mexico

Global Public Health
Establishing a robust One Health (OH) governance is essential for ensuring effective coordination and collaboration among human, animal, and environmental health sectors to prevent and address complex health challenges like zoonoses or antimicrobial ...
Jennifer Hegewisch-Taylor, Anahí Dreser, Alondra Coral Aragón-Gama, María Antonieta Moreno-Reynosa, Celso Ramos Garcia, Arne Ruckert, Ronald Labonté   +6 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observational Cohort Study (Preprint) [PDF]

, 2019
Nicola L. Hawley, Alysa Pomer, Anna C. Rivara, Samantha L. Rosenthal, Rachel L. Duckham, Jenna C. Carlson, Take Naseri, Muagututi‘a Sefuiva Reupena, Melania Selu, Vaimoana Lupematisila, Folla Unasa, Lupesina Vesi, Tracy Fatu, Seipepa Unasa, Kima Faasalele‐Savusa, Abigail Wetzel, Christina Soti‐Ulberg, Angela T. Prescott, Gloria Siufaga, Corina Penaia, Sophie B. To, Lauren C. LaMonica, Viali Lameko, Courtney C. Choy, Scott E. Crouter, Susan Redline, Ranjan Deka, Erin E. Kershaw, Zsolt Urbán, Ryan L. Minster, Daniel E. Weeks, Stephen T. McGarvey   +31 more
openalex   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Fever pitch: Coloniality and contention within community health’s yellow fever response in Kenya

Global Public Health
In January 2022, a number of Yellow Fever cases were identified in Kenya’s Isiolo County for the first time, triggering a national-level response centred on vaccinating residents.
Kathy Dodworth, Brenda N. Mukungu
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Integrated health services for refugee and host populations in Uganda: A qualitative study of stakeholder’s perspectives

Global Public Health
Integration has emerged as a key strategy for promoting equitable access to health services for refugees and host populations. This study explored the perceptions and experiences of stakeholders on the integration of health services for refugees and host
Henry Komakech, Evelyn Baelvina Nyachwo, David Lubogo   +2 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source