Results 71 to 80 of about 2,098,462 (284)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Barriers and facilitators of bystander intervention in response to racism in Colombia

Global Public Health
Racial discrimination is a pervasive global problem. Bystanders who observe racism can intervene to support the targets of racism, but they often fail to do so due to several context-specific barriers.
Minna Lyons, Gayle Brewer, Maria Ines Gandolfo Conceição, Ana Lucía Jaramillo-Sierra, Maria Fernanda Reyes-Rodriguez   +4 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Young people’s lived sexual and reproductive health citizenship: participation and power of youth in Malawi

Global Public Health
This qualitative, focused critical ethnographic study explores how young people’s ‘lived SRH citizenship’ and their active roles realising their sexual and reproductive health (SRH) and rights, shape their agency and participation in decision-making in ...
Jannah Wigle, Stewart Paul, Anne Emanuelle Birn, Brenda Gladstone, Monica Kalolo, Paula Braitstein, Lisa Forman, Lumbani Banda   +7 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Energy metabolism and spermatogenesis

Heliyon
Infertility has become a significant health burden around the globe as it is believed that 15 % of married couples struggle with infertility, with half of the problem accrued to the male.
Damilare Emmanuel Rotimi, Matthew Iyobhebhe, Elizabeth Temidayo Oluwayemi, Olasunkanmi Peter Olajide, Bolanle Adenike Akinsanola, Ikponmwosa Owen Evbuomwan, Rotdelmwa Maimako Asaleye, Oluwafemi Adeleke Ojo   +7 more
doaj  

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Multi-stakeholder perspectives of community pharmacies’ extended services in Al Baha province, Saudi Arabia: A qualitative study

Global Public Health
Community pharmacies have expanded to include new services such as health screenings and medication reviews. However, developing and implementing new applications tends to be challenging and entails comprehensive planning by multiple stakeholders.
Khalid S. Alghamdi, Mahdi H. Alsugoor, Max Petzold, Laith Hussain-Alkhateeb, Christina Ljungberg Persson   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Revitalising strong cultural connections and resilience: Co-designing a pilot Elder-led mentorship program for Indigenous mothers in a remote northern community in Alberta, Canada

Global Public Health
Connecting with traditional knowledge and culture promotes the well-being of Indigenous parents and creates healthy environments for child development. Community Elders in a remote northern community in Alberta, Canada, collaborated with researchers to ...
Stephanie Montesanti, Kayla M. Fitzpatrick, Barbara S.E. Verstraeten, Beverly Tourangeau, Lorraine Albert, Richard T. Oster   +5 more
doaj   +1 more source