Results 121 to 130 of about 2,908,473 (270)

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Durable Thin‐Film Porous Transport Electrodes for High Current Density PEM Water Electrolysis

Advanced Science, EarlyView.
Water electrolysis using porous transport electrodes with sputter‐deposited, ionomer‐free thin films of rutile IrO2 catalyst suppresses Ir dissolution by >10x over other forms of IrOx. The rutile IrO2 catalyst prepared by this readily scalable electrode synthesis method provides stable cell operation at 3 A cm−2 while using low Ir loading (0.4 mg Ir cm−
James L. Young, Diana E. Beltrán, Sarah J. Blair, Ricardo P. M. Duarte, Makenzie R. Parimuha, Haoran Yu, Lonneke van Eijk, Kimberly S. Reeves, Tomas Grejtak, Jorge Martinez, Bennett A. Chao, Jacob Wrubel, Melissa E. Kreider, Elisa M. Miller, Julia D. Lenef, Karen N. Heinselman, Svitlana Pylypenko, David A. Cullen, Guido Bender   +18 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Conservation agriculture practices in Indian mustard (Brassica juncea)-basedcropping systems for enhanced productivity and profitability

The Indian Journal of Agricultural Sciences
The present study was carried out during 2019–20 and 2020–21 at the research farm of ICAR-Directorate of Rapeseed-Mustard Research, Bharatpur, Rajasthan to scale out the conservation agriculture (CA) practices in Indian mustard [Brassica juncea (L ...
R S JAT, H V SINGH, R L CHOUDHARY, M K MEENA, P K RAI   +4 more
doaj   +1 more source

Reaction Mechanism, Challenges, and Strategies of High‐Energy‐Density Sodium‐Ion Batteries

Advanced Science, EarlyView.
Focusing on high‐energy‐density sodium‐ion batteries, this review highlights the advantages offered by conversion‐type cathode materials. The currently studied cathode materials are systematically introduced. By analyzing sulfur, oxygen, and transition metal halides and other conversion‐type cathodes, the key challenges associated with these cathodes ...
Dan Yu, Yuxin Cui, Qinghao Chen, Lu Gao, Xia Liu, Tianci Li, Wenju Zhu, Quanxiang Li, Weimin Kang   +8 more
wiley   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Enhancing Mechanical and Electrochemical Stability of EDLC Electrodes via Crosslinked Polysaccharide Binder Blends

Advanced Science, EarlyView.
Cross‐linked polysaccharide binders derived from potato starch and xanthan gum enable fully water processed EDLC electrodes with improved mechanical integrity and long‐term electrochemical stability at high voltage. ABSTRACT Advancing sustainable energy storage technologies has increased the focus on water processable binders for high‐performance ...
Mahdi Karimi Jafari, Rupesh Singh, Stefano Passerini, Alberto Varzi   +3 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Soil Erosion: Types and Their Mechanism

International Journal of Economic Plants, 2015
Soil erosion is a universal phenomenon. Out of the 328.7 m ha of India’s geographical area about 175 m ha (53.3%) is subjected to soil erosion and some kind of land degradation.
S. G. Telkar, Shivendu Pratap Singh Solanki, Joy Kumar Dey, Kamal Kant   +3 more
doaj