Results 171 to 180 of about 2,908,473 (270)

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

open access: yesAnnals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji   +10 more
wiley   +1 more source

Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi‐Child Cohort Study

open access: yesAnnals of Neurology, EarlyView.
Objective Antiseizure medication (ASM) use during pregnancy has increased over the past decade. However, evidence linking prenatal ASM exposure to neurodevelopmental disorders (NDDs) in offspring remains inconsistent. This study evaluated whether prenatal ASM exposure increases the risk of NDDs in children.
Odile Sheehy   +13 more
wiley   +1 more source

Distortion in the Communication of Nonsignificant Primary Outcomes: The Spin Strategy in Multiple Sclerosis Trials

open access: yesAnnals of Neurology, EarlyView.
Objective Spin refers to reporting strategies that highlight the benefits of an experimental treatment or divert attention from nonsignificant primary outcomes. To assess spin in randomized clinic trials (RCTs) on pharmaceutical efficacy in multiple sclerosis (MS) and explore associated factors.
Marta Mascareñas‐García   +10 more
wiley   +1 more source

Superprotonic Conduction in Donor Co‐Doped Perovskites

open access: yesAngewandte Chemie, EarlyView.
Ceramic proton conductors are promising materials for various applications such as fuel cells. Here, we report superprotonic conduction of BaSc0.8Mo0.1W0.1O2.8 created by donor Mo/W co‐doping into BaScO2.5 (e.g., 10−2 S cm−1 at 193 °C). The high proton conductivity is attributed to high carrier concentration and mobility.
Kensei Umeda   +3 more
wiley   +2 more sources

Clinical and Biological Determinants of Longitudinal Cognitive Function in Patients With GBA1 Variants and Subthalamic Deep Brain Stimulation

open access: yesAnnals of Neurology, EarlyView.
Objective Whether cognitive decline in patients with Parkinson's disease (PD) carrying GBA1 variants is accelerated after subthalamic deep brain stimulation (STN‐DBS) remains controversial. Clarifying long‐term cognitive outcomes is essential for informed decision making.
Moritz A. Loeffler   +8 more
wiley   +1 more source

Ethane Chlorination Toward Vinyl Chloride Synthesis: Mechanistic and Catalytic Perspectives

open access: yesAngewandte Chemie, EarlyView.
Ethane chlorination is emerging as a promising low‐carbon route to vinyl chloride monomer, yet it remains academically underexplored due to the complexity of radical chemistry. As the first focused Minireview on this topic, it offers forward‐looking mechanistic analysis, unveils catalyst evolution pathways, and defines research priorities to accelerate
Xia Wu   +6 more
wiley   +2 more sources

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