Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin
Antibiotics, 2016 Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis.
Pohl Milón +2 more
exaly +3 more sources
Measurement properties of the 30-second sit-to-stand test in post COVID-19 condition: Results from the PYCNOVID randomised controlled trial. [PDF]
PLoS ONEBackgroundThe 30-second sit-to-stand test (30s-STS) is a frequently used measure of functional capacity in post-COVID-19 condition (PCC), but its measurement properties have not been comprehensively investigated.MethodsWe used data from the PYCNOVID ...
Julia Braun +5 more
doaj +2 more sources
The modified 30-second chair stand test (m-30s-CST) is more sensitive than handgrip strength in detecting muscle strength changes and predicting physical performance in hospitalized geriatric patients. [PDF]
PLoS ONEObjectivesTo compare the modified-30s-Chair-Stand-Test (m-30s-CST) with handgrip strength (HGS) in measuring muscle strength in acutely ill geriatric patients.
Walther M W H Sipers +4 more
doaj +2 more sources
Test-retest reliability, concurrent validity, and sensitivity to change of mobility assessments in older adults with urinary incontinence [PDF]
Scientific ReportsUrinary incontinence (UI) significantly impacts locomotor capacity in older adults. Reliable and valid assessment tools are crucial for monitoring treatment outcomes and guiding clinical decisions.
Melda Başer Seçer +1 more
doaj +2 more sources
Mechanistic insights into E. coli recovery from growth arrest [PDF]
Nature CommunicationsBacteria survive hostile conditions by shutting down protein synthesis, but how they restart growth remains poorly understood. Here, we use an E. coli ΔrimM strain, which exhibits a prolonged growth arrest, as a model to investigate how bacteria recover ...
Ahmed H. Hassan +10 more
doaj +2 more sources
A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines
Frontiers in Microbiology, 2021 Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea +4 more
doaj +1 more source
The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. [PDF]
PLoS Biology, 2011 Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three initiation factors (IF1, IF2, IF3 ...
Patricia Julián +6 more
doaj +1 more source
Oilseeds and fats, crops and lipids, 2020 Crambe seeds have numerous industrial applications. Crambe seed oil contains mostly monounsaturated fatty acids. Seeds contain crude protein, amino acid, glucosinolates. They are used in human and animal nutrition.
Ropelewska Ewa, Jankowski Krzysztof J.
doaj +1 more source
De novo design of pimarane diterpenoid compounds as potential alternatives to sarecycline for acne vulgaris treatment [PDF]
Pharmacia, 2023 Acne vulgaris is a prevalent skin disorder that affects both adolescents and adults and has a major psychological impact. Antibiotic resistance is one issue that current therapies, including antibiotics, must address.
Adeola Tawakalitu Kola-Mustapha
doaj +3 more sources
Journal of Epidemiology, 2020 Introduction: To clarify the incidences of metabolic syndrome (MS) and risks in young Japanese adults by gender. Methods: A total of 58,901 adults who had undergone annual health check-ups in 2010 without a diagnosis of MS or missing data were divided ...
Yasuo Haruyama +8 more
doaj +1 more source