Results 61 to 70 of about 297,139 (334)

A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria

open access: yesNature Communications, 2017
The GTP-bound form of initiation factor 2 (IF2) promotes translation initiation by accelerating 50S ribosomal subunit joining the 30S ribosomal initiation complex (30S IC).
Kelvin Caban   +3 more
doaj   +1 more source

A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli

open access: yeseLife, 2014
Ribosome assembly is a complex process involving the folding and processing of ribosomal RNAs (rRNAs), concomitant binding of ribosomal proteins (r-proteins), and participation of numerous accessory cofactors.
Dipali G. Sashital   +5 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes [PDF]

open access: yes, 2017
Assembly of 30S ribosomes involves the hierarchical addition of ribosomal proteins that progressively stabilize the folded 16S rRNA. Here, we use three-color single molecule FRET to show how combinations of ribosomal proteins uS4, uS17 and bS20 in the ...
AD Mackerell Jr.   +47 more
core   +2 more sources

A prediction model to identify hospitalised, older adults with reduced physical performance

open access: yesBMC Geriatrics, 2017
Background Identifying older adults with reduced physical performance at the time of hospital admission can significantly affect patient management and trajectory.
Inge H. Bruun   +4 more
doaj   +1 more source

Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence

open access: yesProtein & Cell, 2014
The in vivo assembly of ribosomal subunits is a highly complex process, with a tight coordination between protein assembly and rRNA maturation events, such as folding and processing of rRNA precursors, as well as modifications of selected bases.
Zhixiu Yang   +11 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Ethical behaviors and wealth: generation Y’s experience [PDF]

open access: yes, 2017
This research investigates if ethical behaviors and personal finances are related using a large scale U.S. random survey called the NLSY97. Fifteen indicators covering both ethical and unethical behaviors are compared to net worth for people in their 20s
Zagorsky, Jay L.
core  

Some issues with Quasi-Steady State Model in Long-term Stability

open access: yes, 2013
The Quasi Steady-State (QSS) model of long-term dynamics relies on the idea of time-scale decomposition. Assuming that the fast variables are infinitely fast and are stable in the long-term, the QSS model replaces the differential equations of transient ...
Chiang, Hsiao-Dong, Wang, Xiaozhe
core   +1 more source

Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation.

open access: yesPLoS Biology, 2013
Regulation of translation initiation is well appropriate to adapt cell growth in response to stress and environmental changes. Many bacterial mRNAs adopt structures in their 5' untranslated regions that modulate the accessibility of the 30S ribosomal ...
Mélodie Duval   +11 more
doaj   +1 more source

Home - About - Disclaimer - Privacy