Results 71 to 80 of about 297,139 (334)
FEATURES OF AMERICAN ISOLATIONISM IN THE 1930S – EARLY 1940S
Американська історія і політика, 2023 The article examines the characteristics of American isolationism as a foreign policy doctrine of the United States in the 30s – early 40s of the XX century, reveals the essence of the term «isolationism» – its origin and application.
Valeriy Pavlenko, Viktoriia Skrypnyk
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Biomolecular and Health Science JournalIntroduction: Osteoarthritis (OA) is one of the most significant contributors to disability regarding limitation in transfer and ambulation. Extracorporeal shockwave therapy (ESWT) has recently been developed as regenerative therapy.
Petrina Theda Philothra +5 more
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Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
Nature Communications, 2016 During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain.
Kien Nguyen, Paul C. Whitford
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FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Nucleic Acids Research, 2013 Ribosome biogenesis is a tightly regulated, multi-stepped process. The assembly of ribosomal subunits is a central step of the complex biogenesis process, involving nearly 30 protein factors in vivo in bacteria.
Q. Guo +9 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Spatial organization of bacterial transcription and translation
, 2016 In bacteria such as $\textit{Escherichia coli}$, DNA is compacted into a nucleoid near the cell center, while ribosomes$-$molecular complexes that translate messenger RNAs (mRNAs) into proteins$-$are mainly localized at the poles.
Castellana, Michele +2 more
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Adiabatic Magnetization of Superconductors as a High-Performance Cooling Mechanism [PDF]
, 2008 The adiabatic magnetization of a superconductor is a cooling principle proposed in the 30s, which has never been exploited up to now. Here we present a detailed dynamic description of the effect, computing the achievable final temperatures as well as the
A. C. Rose-Innes +6 more
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(1S,5R,7R,30S)-14-Deoxyisogarcinol
Acta Crystallographica Section E, 2012 The title compound, C38H50O5 {systematic name: 10-(3-hydroxybenzoyl)-2,2,7,7-tetramethyl-3,6,8-tris(3-methylbut-2-enyl)-3,4,4a,5,6,7-hexahydro-4a,8-methano-2H-cycloocta[b]pyran-9,11(8H)-dione}, is a polyisoprenylated benzophenone, isolated for the first ...
Ranjeet Kaur +2 more
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