Results 31 to 40 of about 378,847 (261)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Axial Spondyloarthritis in the Era of Precision Medicine: Biomarkers, Microbiota, and Multimodal Therapy

Quality in Sport
Introduction and Purpose Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting the axial skeleton. It includes both radiographic (r-axSpA) and non-radiographic (nr-axSpA) forms.
Karolina Kopeć, Aleksandra Bartoszek , Julia Adamiuk , Agnieszka Marut, Marta Biskup, Jagoda Misiuk, Adriana Skuba, Katarzyna Załuska, Wiktoria Śmigiel , Agnieszka Świdniak   +9 more
doaj   +1 more source

In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture

Molecules, 2020
Complexes combining nucleic acids with lipids and polymers (lipopolyplexes) show great promise for gene therapy since they enable compositional, physical and functional versatility to be optimized for therapeutic efficiency.
Juan L. Paris, Filipe Coelho, Alexandra Teixeira, Lorena Diéguez, Bruno F. B. Silva, Sara Abalde-Cela   +5 more
doaj   +1 more source

An Approach for Shipping Emissions Estimation in Ports: The Case of Ro–Ro Vessels in Port of Vigo

Journal of Marine Science and Engineering, 2023
Despite most atmospheric emissions being produced by vessels when navigating at sea, they are also important when in port because of their proximity to urban areas and their harmful effects on climate change and health.
Ana B. Albo-López, Camilo Carrillo, Eloy Díaz-Dorado   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

2-(3-Cyano-4-{3-[1-(2-hydroxyethyl)-3,3-dimethyl-1,3-dihydroindol-2-ylidene]prop-2-enyl}-5,5-dimethyl-5H-furan-2-ylidene)malononitrile

Acta Crystallographica Section E, 2014
The title compound, C25H24N4O2, adopts a cisoid configuration and has twofold orientational disorder of the 2-hydroxyethyl group. The molecule is twisted from planarity so that the dihedral angle between the terminating indol-2-ylidene and the furan-2 ...
Graeme J. Gainsford, M. Delower H. Bhuiyan, Andrew J. Kay   +2 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Comparison of the impact of e-cigarettes and new tobacco heating devices on the human body and their potential in the fight against smoking

Journal of Education, Health and Sport, 2022
Nicotine is one of the most common stimulants used by humans in the world. Its addictive potential is almost the same as that of cocaine. [1] The most popular way of delivering nicotine to the body, which is cigarette smoking, has many negative effects,
Kamil Pondel, Kinga Kawałko, Krzysztof Bielewicz, Katarzyna Skowrońska, Patrycja Baciur   +4 more
doaj   +1 more source