Results 61 to 70 of about 2,942,407 (405)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Testosterone therapy for hypoactive sexual desire disorder in women

Quality in Sport
Introduction and Purpose: Testosterone plays a pivotal role in women’s sexual health, influencing sexual desire, arousal, and satisfaction. This hormone, primarily produced in the ovaries, adrenal glands, and adipose tissue, declines with age ...
Jagoda Misiuk Misiuk, Karolina Kopeć, Aleksandra Bartoszek, Julia Adamiuk, Agnieszka Marut, Marta Biskup, Adriana Skuba, Katarzyna Załuska, Sylwia Nykiel, Agnieszka Świdniak   +9 more
doaj   +1 more source

Long-term prognostic impact of paravalvular leakage on coronary artery disease requires patient-specific quantification of hemodynamics

Scientific Reports, 2022
Transcatheter aortic valve replacement (TAVR) is a frequently used minimally invasive intervention for patient with aortic stenosis across a broad risk spectrum.
Seyedvahid Khodaei, Louis Garber, Julia Bauer, Ali Emadi, Zahra Keshavarz-Motamed   +4 more
doaj   +1 more source

A framework and user interface for automatic region based segmentation algorithms [PDF]

, 2006
In this paper we describe a framework and tool developed for running and evaluating automatic region based segmentation algorithms. The tool was designed to allow simple integration of existing and future segmentation algorithms, both single image based
Adamek, Tomasz, Keenan, Gordon, McGuinness, Kevin, O'Connor, Noel E.   +3 more
core  

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Axial Spondyloarthritis in the Era of Precision Medicine: Biomarkers, Microbiota, and Multimodal Therapy

Quality in Sport
Introduction and Purpose Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting the axial skeleton. It includes both radiographic (r-axSpA) and non-radiographic (nr-axSpA) forms.
Karolina Kopeć, Aleksandra Bartoszek , Julia Adamiuk , Agnieszka Marut, Marta Biskup, Jagoda Misiuk, Adriana Skuba, Katarzyna Załuska, Wiktoria Śmigiel , Agnieszka Świdniak   +9 more
doaj   +1 more source

Is 3C 310 blowing bubbles?

The Astrophysical Journal, 1984
On presente des observations radio de la source double, large, proche, 3C 310 qui presente une structure radio complexe a faible echelle (enveloppes et filaments) dans des lobes diffus de faible brillance. La morphologie en forme de ballon de certaines des caracteristiques suggere qu'il peut s'agir de la frontiere brillante de «bulles» de gaz chaud ...
E. B. Fomalont, W. van Breugel
openaire   +2 more sources

Does wage rank affect employees' well-being? [PDF]

, 2008
How do workers make wage comparisons? Both an experimental study and an analysis of 16,000 British employees are reported. Satisfaction and well-being levels are shown to depend on more than simple relative pay.
Bolton Gary E., Borowiak Dale S., Bradburn Norman, Brown Gordon D.A., Cox James, Cully Mark, Cully Mark, Easterlin Richard A., Frank Robert H., Freeman Richard B., Frey Bruno S., Helson Harry, Hills Frederick S., Law Kenneth S., Layard Richard, Levine David I., Lommerud Kjell E., Lopes Lola L., Marmot Michael G., Palmore Erdman, Parducci Allen, Parducci Allen, Patchen Martin, Rabin Matthew, Runciman W. Garry, Van Praag Bernard M. S., Volkmann John, Wall Toby D.   +27 more
core   +1 more source

The Long Term Effects of a 12‐Session Community Exercise Program on Health Measures in Cancer Patients

Aging and Cancer, EarlyView.
ABSTRACT Purpose To assess the long‐term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non‐metastatic and metastatic patients.
Isaac Oppong, Roozbeh Naemi
wiley   +1 more source

Structure and pseudosymmetry of cholesterol at 310 K [PDF]

Acta Crystallographica Section B Structural Science, 2002
The structure of cholesterol above the (304.8 K) phase transition, previously published in preliminary form [Hsu & Nordman (1983). Science, 220, 604–606], has been fully refined using augmented X-ray data. The crystals are triclinic, space group P1, with (reassigned) cell parameters a = 27.565 (10), b = 38.624 (16), c = 10.748 (4) Å, α = 93.49 (3),
Jeff W. Kampf, Leh-Yeh Hsu, Christer E. Nordman   +2 more
openaire   +3 more sources