Results 31 to 40 of about 172,274 (316)

$3$-Kenmotsu Manifolds [PDF]

open access: yesLobachevskii Journal of Mathematics, 41 (2020), 320-325, 2019
In this paper, a $3$-Kenmotsu structure is defined on a $4n+1$ dimensional manifold where such structure seems to be never studied before.
arxiv   +1 more source

Interference with lactate metabolism by mmu-miR-320-3p via negatively regulating GLUT3 signaling in mouse Sertoli cells

open access: yesCell Death and Disease, 2018
Disruption of the nursery function in Sertoli cells (SCs) by reducing lactate production, a preferred energy substrate for developed germ cells (spermatocytes and spermatids), is tightly associated with spermatogenic failure such as SC-only syndrome ...
Li-li Zhang   +6 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

open access: yesFEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley   +2 more
wiley   +1 more source

A setup for Seebeck coefficient measurement through controlled heat pulses [PDF]

open access: yesReview of Scientific Instruments 90, 116101 (2019), 2019
A setup is designed for measuring the Seebeck coefficient (S) of materials in form of thin film, bar and wire. The main feature of this setup is control in heating and cooling cycles. In this setup heat pulse is used to generate the temperature gradient. To demonstrate the capabilities of this setup, S vs T of standard wire samples such as Au-Fe (0.07 \
arxiv   +1 more source

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1

open access: yesOncoTarget, 2016
Colorectal cancer (CRC) is the third most common cancer causing high mortality rates world-wide. Delineating the molecular mechanisms leading to CRC development and progression, including the role of microRNAs (miRNAs), are currently being unravelled at ...
Radhakrishnan Vishnubalaji   +7 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha   +6 more
wiley   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Book Review: Donald L. Horowitz: Constitutional Change and Democracy in Indonesia

open access: yesJournal of Current Southeast Asian Affairs, 2013
Book Review of the Monograph: Horowitz, Donald L. (2013), Constitutional Change and Democracy in Indonesia ; Cambridge: Cambridge University Press (= Series: Problems of International Politics, 4), ISBN: 9781107641150, 342 ...
Dirk Tomsa
doaj  

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