Results 81 to 90 of about 2,709,955 (319)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng   +15 more
wiley   +1 more source

Hybrid Political Institutions and Governability: The Budgetary Process in Brazil Hibridez Institucional e Governabilidade: O Processo Orçamentário no Brasil

open access: yesJournal of Politics in Latin America, 2009
In this paper we take a close look at some of the particular pathways by which majoritarian and consensual institutions affect governability. We demonstrate that the mix of majoritarian and consensual institutions found within a country can influence ...
Carlos Pereira, Salomon Orellana
doaj  

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik   +13 more
wiley   +1 more source

Book Review: Mertha, Andrew: Brothers in Arms: Chinese Aid to the Khmer Rouge, 1975–1979

open access: yesJournal of Current Southeast Asian Affairs, 2015
Book Review of the Monograph: Mertha, Andrew (2014), Brothers in Arms: Chinese Aid to the Khmer Rouge, 1975–1979.
Chow Bing NGEOW
doaj  

Pind. fr. 321 Sn.-Maehl. delendum

open access: diamond, 2021
Stefano Vecchiato
openalex   +1 more source

Cold hardening and dehardening in Salix [PDF]

open access: yes, 2003
The variation in cold hardiness in Salix in the autumn was investigated using clones of different geographic origins. In late growing season, the variation was small and inversely related to a phenotypic variation in potential growth rate.
Lennartsson, Mattias
core  

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

open access: yesAdvanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang   +11 more
wiley   +1 more source

Presidential Control of High Courts in Latin America: A Long-term View (1904-2006) Control presidencial de las cortes supremas en América Latina. Una mirada histórica (1904-2006)

open access: yesJournal of Politics in Latin America, 2009
In many Latin American countries the executive branch manipulatesthe composition of the Supreme Court, and judicial independence hasremained elusive. Because high courts can exercise judicial review and influencelower courts, incoming presidents often ...
Aníbal Pérez-Liñán   +1 more
doaj  

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

open access: yesAdvanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang   +22 more
wiley   +1 more source

I Want It All, and I Want It Now: The Political Manipulation of Argentina’s Provincial High Courts I Want It All, and I Want It Now: La manipulación política de las Cortes Supremas provinciales en Argentina

open access: yesJournal of Politics in Latin America, 2012
Provincial supreme courts are important players in local politics because justices can affect the interest of the ruling governors; however, no research has addressed the factors that affect judicial turnover in provincial high courts in new democracies.
Andrea Castagnola
doaj  

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