Results 111 to 120 of about 230,641 (265)

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, EarlyView.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Biological activities of metal oxide nanoparticles modified with hexadeca-substituted cobalt(ii) phthalocyanine bearing fluorinated substituents. [PDF]

RSC Adv
Öztürk NF.
europepmc   +1 more source

Impact of the pancreatic enzyme replacement therapy (PERT) shortage on prescribing in England: Analysis of national data

British Journal of Clinical Pharmacology, EarlyView.
Aim Pancreatic enzyme replacement therapy (PERT) is essential for the management of pancreatic exocrine insufficiency. Since June 2023, the United Kingdom has been affected by a global shortage of PERT. We investigated the impact of this shortage on national prescribing trends for Creon, Nutrizym, Pancrex and Pangrol.
Teena S. Varghese, Mary E. Phillips, Louis Fisher, Helen Fitt, Adam Frampton, Christopher Wood, Agnieszka Lemanska   +6 more
wiley   +1 more source

mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth. [PDF]

Genes Dev
Lin DH, Elcavage LE, Khalizeva E, Bartel DP.   +3 more
europepmc   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Chemical Characterization and Aquatic Toxicity of Firefighting Runoff-Linking Organic Profiling to Multi-Trophic Bioassays in the One Health Framework. [PDF]

Molecules
Trawińska A, Tankiewicz M, Pająk K, Cieszyńska-Semenowicz M, Reindl AR.   +4 more
europepmc   +1 more source

Site 322

, 1976
C.D. Hollister, C. Craddock, Y.A. Bogdanov, N.T. Edgar, J.M. Gieskes, B.U. Haq, J.R. Lawrence, F. Rogl, H.-J. Schrader, B.E. Tucholke, W.R. Vennum, F.M. Weaver, V.N. Zhivago   +12 more
openaire   +1 more source

Prosocial behaviour in primary and secondary school students. Effects of the CYBUPRE intervention

British Educational Research Journal, EarlyView.
Abstract Prosocial behaviour is regarded as a critical factor in reducing aggressive behaviours among peers, both in physical settings and virtual spaces. This variable facilitates the enhancement of social relationships, promoting empathy, deep listening, physical and verbal service, and even solidarity, among other benefits.
Mercedes Chicote‐Beato, Ana Rosa Bodoque‐Osma, Fernando Martins, Sixto González‐Víllora   +3 more
wiley   +1 more source

miR-424(322)^~503 impairs colon cancer progression driven by PTEN deficiency. [PDF]

Cell Death Dis
Vidal-Sabanés M, Bonifaci N, Navaridas R, Egea J, Encinas M, Rodriguez-Barrueco R, Silva JM, Matias-Guiu X, Tarragona J, Llobet-Navas D, Dolcet X.   +10 more
europepmc   +1 more source