Results 11 to 20 of about 2,466,814 (376)

Anomalous outbursts of H 1743-322 [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2019
Abstract Using soft (1.5–3 keV) and hard (3–12 keV) photon counts of All Sky Monitor (ASM) in Rossi X-ray Timing Explorer (RXTE) satellite, we have proposed recently that there is a significant time lag between the infall time-scales of two components in the Two-Component Advective Flow paradigm, where a standard slow moving Keplerian ...
Sandip K. Chakrabarti, Arindam Ghosh
openaire   +2 more sources

Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: The trigeminal neuralgia experience [PDF]

open access: yes, 2018
Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.
Bendtsen, Lars   +10 more
core   +4 more sources

Opinion on the re‐evaluation of lecithins (E 322) as a food additive in foods for infants below 16 weeks of age and follow‐up of its re‐evaluation as food additive for uses in foods for all population groups

open access: yesEFSA journal. European Food Safety Authority, 2020
Lecithins (E 322) were re‐evaluated in 2017 by the former EFSA Panel on Food Additives and Nutrient sources added to Food (ANS). As follow‐up to that assessment, the Panel on Food Additives and Flavourings (FAF) was requested to assess the safety of ...
M. Younes   +23 more
semanticscholar   +1 more source

MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR

open access: yesInternational Journal of Molecular Sciences, 2020
Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms ...
H. Geng   +6 more
semanticscholar   +1 more source

Bullying Roles in Changing Contexts: The Stability of Victim and Bully Roles from Primary to Secondary School [PDF]

open access: yes, 2004
The present study was conducted to predict bullying roles over a six years time period and across contexts differing in the degree of peer hierarchies.
Brodbeck, Felix C.   +4 more
core   +1 more source

Identification of the extraction structure of H− ions by Hα imaging spectroscopy

open access: yesNew Journal of Physics, 2013
Extraction structure of negative hydrogen ions (H ^− ) (i.e. the regions where H ^− ions are effectively extracted from the plasma) was obtained using hydrogen Balmer- α (H _α ) imaging spectroscopy and cavity ring-down spectroscopy. The H ^− ion density
K Ikeda   +7 more
doaj   +1 more source

miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

open access: yesNature Communications, 2016
Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers.
Shaohua Xu   +20 more
semanticscholar   +1 more source

miR-322/-503 rescues myoblast defects in myotonic dystrophy type 1 cell model by targeting CUG repeats

open access: yesCell Death and Disease, 2020
Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and ...
Xiaopeng Shen   +8 more
semanticscholar   +1 more source

miR‐322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4

open access: yesCNS Neuroscience & Therapeutics, 2020
Failure of neural tube closure resulting from excessive apoptosis leads to neural tube defects (NTDs). NADPH oxidase 4 (NOX4) is a critical mediator of cell growth and death, yet its role in NTDs has never been characterized.
Yusi Liu   +15 more
semanticscholar   +1 more source

How helpful is NHS Direct? Postal survey of callers [PDF]

open access: yes, 2000
NHS Direct, the new 24 hour telephone advice line staffed by nurses, was established to “provide easier and faster information for people about health, illness and the NHS so that they are better able to care for themselves and their families.” In ...
Knowles, E.   +3 more
core   +1 more source

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