Results 11 to 20 of about 2,466,814 (376)
Anomalous outbursts of H 1743-322 [PDF]
Abstract Using soft (1.5–3 keV) and hard (3–12 keV) photon counts of All Sky Monitor (ASM) in Rossi X-ray Timing Explorer (RXTE) satellite, we have proposed recently that there is a significant time lag between the infall time-scales of two components in the Two-Component Advective Flow paradigm, where a standard slow moving Keplerian ...
Sandip K. Chakrabarti, Arindam Ghosh
openaire +2 more sources
Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: The trigeminal neuralgia experience [PDF]
Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.
Bendtsen, Lars+10 more
core +4 more sources
Lecithins (E 322) were re‐evaluated in 2017 by the former EFSA Panel on Food Additives and Nutrient sources added to Food (ANS). As follow‐up to that assessment, the Panel on Food Additives and Flavourings (FAF) was requested to assess the safety of ...
M. Younes+23 more
semanticscholar +1 more source
MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR
Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms ...
H. Geng+6 more
semanticscholar +1 more source
Bullying Roles in Changing Contexts: The Stability of Victim and Bully Roles from Primary to Secondary School [PDF]
The present study was conducted to predict bullying roles over a six years time period and across contexts differing in the degree of peer hierarchies.
Brodbeck, Felix C.+4 more
core +1 more source
Identification of the extraction structure of H− ions by Hα imaging spectroscopy
Extraction structure of negative hydrogen ions (H ^− ) (i.e. the regions where H ^− ions are effectively extracted from the plasma) was obtained using hydrogen Balmer- α (H _α ) imaging spectroscopy and cavity ring-down spectroscopy. The H ^− ion density
K Ikeda+7 more
doaj +1 more source
Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers.
Shaohua Xu+20 more
semanticscholar +1 more source
Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and ...
Xiaopeng Shen+8 more
semanticscholar +1 more source
Failure of neural tube closure resulting from excessive apoptosis leads to neural tube defects (NTDs). NADPH oxidase 4 (NOX4) is a critical mediator of cell growth and death, yet its role in NTDs has never been characterized.
Yusi Liu+15 more
semanticscholar +1 more source
How helpful is NHS Direct? Postal survey of callers [PDF]
NHS Direct, the new 24 hour telephone advice line staffed by nurses, was established to “provide easier and faster information for people about health, illness and the NHS so that they are better able to care for themselves and their families.” In ...
Knowles, E.+3 more
core +1 more source