Results 201 to 210 of about 2,375,913 (328)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Building a Bridge Between Ambient MS and LC‐MS by Non‐Exhaustive Microdesorption

open access: yesAngewandte Chemie International Edition, Accepted Article.
Ambient mass spectrometry (AMS) offers rapid screening but faces challenges in analyzing complex samples due to high matrix effects and limited selectivity. The absence of a separation step can also lead to false positives due to the isomers or isobars.
Wei Zhou, Janusz Pawliszyn
wiley   +1 more source

PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes

open access: yesAngewandte Chemie International Edition, Accepted Article.
Site‐directed mutagenesis (SDM) is a key driver for many biochemical investigations and biotechnological applications. Despite decades of development, it is still difficult to perform SDM on some sequences, including highly repetitive ones, because polymerase chain reaction (PCR) is often used as the most effective method for SDM, but results in ...
Mingkuan Lyu   +3 more
wiley   +1 more source

Correction: Developing Disability-Focused Pre-Health and Health Professions Curricula. [PDF]

open access: yesJ Med Humanit
Bracken RC   +7 more
europepmc   +1 more source

A Multistate Adaptive System of Topologically Distinct Chiral Assemblies

open access: yesAngewandte Chemie International Edition, EarlyView.
This article presents a non‐covalent multistate system with seven distinct assembly products across solid and liquid states, generated from a single supramolecular synthon. Thermodynamic pathways between these states are switchable with simple external triggers.
Wiktoria Adamska   +6 more
wiley   +1 more source

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