Results 241 to 250 of about 2,472,075 (322)

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea

open access: yesChemMedChem, EarlyView.
Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka   +11 more
wiley   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

open access: yesChemMedChem, EarlyView.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco   +11 more
wiley   +1 more source

Metamorphosis of Multilayered‐(NH4)2V7O16 Squares to Zinc Vanadate and w‐ZnO Nanoparticles via Zinc Metalation through Atomic Layer Deposition: Precision and Sustainability in Material Transformation

open access: yesChemistry–Methods, EarlyView.
Vapor phase metalation (VPM) enables Angstrom‐scale functionalization of (NH4)2V7O16 nanostructures using diethylzinc. This solvent‐free, gas‐phase method induces structural and magnetic transformations, aligning with circular economy goals. VPM enhances material properties for spintronics, neuromorphic computing, biomagnetism, and sustainable ...
Mabel. A. Moreno   +4 more
wiley   +1 more source

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