Results 251 to 260 of about 2,375,913 (328)

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

open access: yesBMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu   +9 more
wiley   +1 more source

Pathways to Sustainable Consumption Apps Adoption: Extending UTAUT2 With Personal Values and Behaviors

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Sustainable consumption apps (SCAs) support consumer transitions toward responsible purchasing decisions. This study advances understanding of SCAs adoption pathways by developing a comprehensive framework that integrates the Unified Theory of Acceptance and Use of Technology (UTAUT2) with dimensions from the value‐belief‐norm (VBN) theory ...
Giovanna Pegan   +2 more
wiley   +1 more source

Beyond the Evidence: How Race, Chronological Age, and Developmental Age Shape Juror Verdicts in Sexual Assault Cases

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT There is an overrepresentation of Indigenous people (both as accused and victims of crime) and those with developmental delays in the Canadian Criminal Justice System. The current research examined the influence of defendant and victim race (involving Indigenous people), as well as defendant developmental and chronological age, on mock‐jurors’
Bailey M. Fraser   +4 more
wiley   +1 more source

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