Results 51 to 60 of about 308,936 (313)
MSCL measurements from IODP Hole 322-C0011B
, 2012 Update on 2018-01-19: Parameter 'Susceptibility, volume' has been converted from [10**-5 SI] to [10**-6 SI].
Saneatsu Saito (5926976) +7 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Beyond Democratic Tolerance: Witch Killings in Timor-Leste
Journal of Current Southeast Asian Affairs, 2015 Newly democratising states experience challenges in reconciling “traditional†or “customary†dispute resolution practices with newly established state-based legal systems based on the rule of law. For Timor-Leste, these tensions are pronounced in
Rebecca Strating, Beth Edmondson
doaj
CNS-analysis from IODP Hole 322-C0012A
, 2012 Geocode = [m CSF-A] Top Core depth (below sea ...
Saneatsu Saito (5926976) +7 more
core +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Low-Level Corruption Tolerance: An “Action-Based†Approach for Peru and Latin America
Journal of Politics in Latin America, 2015 Since the beginning of the past decade, the tolerance of corruption by citizens of most Latin American countries has become a concept in its own right within the broader study of corruption. This construct, however, lacks a systematic approach and is yet
Joseph Pozsgai Alvarez
doaj
CNS-analysis from IODP Hole 322-C0011B
, 2012 Geocode = [m CSF-A] Top Core depth (below sea ...
Saneatsu Saito (5926976) +7 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Advanced Science, EarlyView.Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao +7 more
wiley +1 more source