Results 81 to 90 of about 2,494,019 (274)
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Introduction: New Forms of Voter Mobilization in Southeast Asia
Journal of Current Southeast Asian Affairs, 2010 Southeast Asia in the twenty-first century is no longer what it used to be, at least not at its ASEAN core. By the 1990s, competitive elections had (re)emerged as the primary mechanism for the assumption of state office in the Philippines and Thailand ...
Eva-Lotta E. Hedman, Andreas Ufen
doaj
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Journal of Current Southeast Asian Affairs, 2010 Book Review of the edited issue: Clarke, Matthew, Ismet Fanany, and Sue Kenny (eds.) (2010), Post-Disaster Reconstruction: Lessons from Aceh, London/ Washington DC: Earthscan ISBN 978-1-84407-879-0, 266 ...
Antje Missbach
doaj
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Journal of Politics in Latin America, 2009 Government and organized criminal groups co-exist in uneasy equilibrium. Criminal groups adjust their behavior as a function of their own goals and resources in relation to inter-group cooperation and conflict, dynamic markets, and public policies ...
Matthew M. Taylor, John Bailey
doaj
International Journal of Polymer Science, 2016 The purpose of this study was to enhance the scratch resistance of polycarbonate copolymer by using 3,3′-dibenzoyl-4,4′-dihydroxybiphenyl (DBHP) monomer, containing benzoyl moieties on the ortho positions.
Hohyoun Jang +8 more
doaj +1 more source
Advanced Science, EarlyView.This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang +6 more
wiley +1 more source
The European Union’s Myanmar Policy: Focused or Directionless?
Journal of Current Southeast Asian Affairs, 2015 What is the European Union (EU) trying to achieve in Myanmar? Is the EU speaking with one voice and acting collectively (and does it really matter)? Were the sanctions lifted too early?
Jörn Dosch, Jatswan S. Sidhu
doaj
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source