Results 91 to 100 of about 255,512 (342)

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

open access: yesAdvanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan   +6 more
wiley   +1 more source

Editorial: On China–Myanmar Relations

open access: yesJournal of Current Southeast Asian Affairs, 2012
For two decades, the growing relationship between the People’s Republic of China and the Myanmar-controlled junta was either ignored or avoided in the United States public discourse.
David I. Steinberg
doaj  

Paper 327

open access: yes
Student response paper submitted for course ACA-401/ACA-401D.
openaire   +2 more sources

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang   +18 more
wiley   +1 more source

Timor-Leste’s Foreign Policy: Securing State Identity in the Post-Independence Period

open access: yesJournal of Current Southeast Asian Affairs, 2014
This paper examines some of the major ideational aspects of Timor-Leste’s foreign policy orientation in the post-independence period. Drawing upon the constructivist accounts of state behaviour, the paper situates Timorese leaders’ foreign policy ...
Selver B. Sahin
doaj  

Do Managerial Objectives Drive Bad Acquisitions?

open access: yes, 1989
This paper documents for a sample of 327 US acquisitions between 1975 and 1987 three forces that systematically reduce the announcement day return of bidding firms. The returns to bidding shareholders are lower when their firm diversifies, when it buys a
R. Morck   +2 more
semanticscholar   +1 more source

Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation.

open access: yesBiochemistry, 2010
Previous studies demonstrate that nitric oxide (NO) promotes p53 transcriptional activity by a classical DNA damage responsive mechanism involving activation of ATM/ATR and phosphorylation of p53.
V. Yakovlev   +4 more
semanticscholar   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

open access: yesAdvanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei   +11 more
wiley   +1 more source

Evaluating Competing “Democratic” Discourses: The Impact on Human Rights Protection in Southeast Asia

open access: yesJournal of Current Southeast Asian Affairs, 2014
This paper evaluates the impact of competing “democratic” discourses on human rights protection in Southeast Asia. The authors identify three key discourses emanating from a set of national governmental policies, advocacy positions promoted by both ...
James Gomez, Robin Ramcharan
doaj  

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