Results 101 to 110 of about 255,512 (342)

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

open access: yesAdvanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai   +8 more
wiley   +1 more source

An Agreement to Disagree: The ASEAN Human Rights Declaration and the Absence of Regional Identity in Southeast Asia

open access: yesJournal of Current Southeast Asian Affairs, 2014
ASEAN’s engagement with human rights culminated in the creation of the ASEAN Human Rights Declaration in 2012. The Declaration is fascinating in three ways: Its institutional origins are surprising, it was agreed upon by states with very different ...
Mathew Davies
doaj  

IRC volume 28 issue 327 Cover and Back matter [PDF]

open access: bronze, 1946
Produlls Gevaerl   +2 more
openalex   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

open access: yesAdvanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong   +9 more
wiley   +1 more source

Case Study: The Myanmar and Bangladesh Maritime Boundary Dispute in the Bay of Bengal and Its Implications for South China Sea Claims

open access: yesJournal of Current Southeast Asian Affairs, 2012
This paper seeks to review the pertinent Myanmar and Bangladesh history in overlapping maritime territorial claims leading up to the September 2011 International Tribunal for the Law of the Sea (ITLOS) case: Dispute Concerning Delimitation of the ...
Ravi A. Balaram
doaj  

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

open access: yesAdvanced Science, EarlyView.
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun   +13 more
wiley   +1 more source

Navigating the Security Dilemma: China, Vietnam, and the South China Sea

open access: yesJournal of Current Southeast Asian Affairs, 2012
Competition and conflict in the South China Sea involves many nations due to its resources and vital sea lanes. However, it is China which increasingly serves as a common denominator of intensifying anxiety for its South China Sea maritime neighbours due
Jason J. Blazevic
doaj  

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