Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Post-Processing PEEK 3D-Printed Parts: Experimental Investigation of Annealing on Microscale and Macroscale Properties. [PDF]
Polymers (Basel)Adamson M, Eslami B.
europepmc +1 more source
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
wiley +1 more source
Ce-doped nano-Fe-TiO<sub>2</sub> composites for photocatalytic degradation of naphthol blue black in aqueous medium. [PDF]
RSC AdvSuhan MBK, Bahar MK, Islam MS.
europepmc +1 more source
Instant Writing of Conductive Interface on MOF Single Crystal by Ultrafast Laser
Advanced Science, EarlyView.Current device fabrication strategies lack capacity for tailoring ideal electrical interface in individual MOF single crystals. An ultrafast laser approach is developed that in situ constructs stable conductive interface on MOF single crystal scale while maintaining its crystalline integrity.
Dongsheng Huang +11 more
wiley +1 more source
Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets. [PDF]
Discov OncolLai X, Wu L, Lin P, You L, Ye J.
europepmc +1 more source
Advanced Science, EarlyView.A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen +16 more
wiley +1 more source
Effect of Limosilactobacillus reuteri DSM17938 to prevent antibiotic-associated diarrhea in children: prospective, multi-center, randomized, placebo-controlled clinical trial (PEARL Study). [PDF]
Eur J PediatrDinleyici EC +13 more
europepmc +1 more source
Advanced Microfluidics for Single Cell‐Based Cancer Research
Advanced Science, EarlyView.Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro +10 more
wiley +1 more source
Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis. [PDF]
Sci RepTian L +5 more
europepmc +1 more source