Results 11 to 20 of about 2,220,902 (323)

Autoimmunity against laminin 332

Frontiers in Immunology, 2023
Laminin 332 is a heterotrimeric structural protein of the basal membrane zone (BMZ) of the skin and adjacent mucosal tissues. The importance of laminin 332 for the structural integrity of the BMZ is demonstrated by mutations in any of the three genes encoding for its three chains causing variants of junctional epidermolysis bullosa.
Sabrina Patzelt, Enno Schmidt, Enno Schmidt   +2 more
openaire   +4 more sources

Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid

Frontiers in Immunology, 2021
Anti-laminin 332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by predominant mucosal lesions and autoantibodies against laminin 332.
Stephanie Goletz, Federica Giurdanella, Maike M. Holtsche, Miranda Nijenhuis, Barbara Horvath, Gilles F. H. Diercks, Detlef Zillikens, Takashi Hashimoto, Enno Schmidt, Enno Schmidt, Hendri H. Pas   +10 more
doaj   +2 more sources

Effect of Limosilactobacillus fermentum 332 on physicochemical characteristics, volatile flavor components, and Quorum sensing in fermented sausage

Scientific Reports, 2023
The effects of Limosilactobacillus fermentum 332 on quality characteristics in fermented sausage were explored in terms of physicochemical characteristics, volatile flavor components, and Quorum sensing (QS).
Yue Gu, R. Qiao, B. Jin, Yinfeng He, Jian-Bin Tian   +4 more
semanticscholar   +1 more source

Anti-Laminin 332-Type Mucous Membrane Pemphigoid

Biomolecules, 2022
Anti-laminin (LM) 332-type mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease and was originally discovered as anti-epiligrin cicatricial pemphigoid.
Luhuai Shi, Xiaoguang Li, H. Qian
semanticscholar   +1 more source

CT facilitates improved diagnosis of adult intestinal malrotation: a 7-year retrospective study based on 332 cases

Insights into Imaging, 2021
Objective To classify adult intestinal malrotation by CT. Methods This retrospective study enrolled adults diagnosed with intestinal malrotation who underwent abdominal CT at our institution between June 1, 2013, and August 30, 2020.
Z. Xiong, Yaqi Shen, J. Morelli, Zhen Li, Xuemei Hu, D. Hu   +5 more
semanticscholar   +1 more source

LAMININ 332 IS INDISPENSABLE FOR HOMEOSTATIC EPIDERMAL DIFFERENTIATION PROGRAMS.

Journal of Investigative Dermatology, 2021
The skin epidermis is attached to the underlying dermis by a laminin 332-rich basement membrane. Consequently, loss of laminin 332 leads to the severe blistering disorder epidermolysis bullosa junctionalis in human and animals.
Raneem Tayem, C. Niemann, M. Pesch, Jessica Morgner, C. Niessen, S. Wickström, M. Aumailley   +6 more
semanticscholar   +1 more source

Laminin 332 in cancer: when the extracellular matrix turns signals from cell anchorage to cell movement.

Seminars in Cancer Biology, 2020
Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein consists of the heterotrimeric assembly of three subunits - α3, β3, and γ2 - and its multifunctionality relies on a number of extracellular proteolytic processing
P. Rousselle, J. Scoazec
semanticscholar   +1 more source

Subunit-Specific Reactivity of Autoantibodies Against Laminin-332 Reveals Direct Inflammatory Mechanisms on Keratinocytes

Frontiers in Immunology, 2021
Laminin-332 pemphigoid is a rare and severe autoimmune blistering disease, caused by IgG autoantibodies targeting laminin-332 in the dermal-epidermal basement zone.
L. Bao, Jing Li, F. Solimani, D. Didona, Pratikkumar A. Patel, Xiaoguang Li, H. Qian, N. Ishii, T. Hashimoto, M. Hertl, K. Amber   +10 more
semanticscholar   +1 more source

Gentamicin Induces Laminin 332 and Improves Wound Healing in Junctional Epidermolysis Bullosa Patients with Nonsense Mutations

Molecular Therapy, 2020
Generalized severe junctional epidermolysis bullosa (GS-JEB) is an incurable and fatal autosomal recessively inherited blistering skin disease caused by mutations in the LAMA3, LAMB3, or LAMC2 genes.
A. Kwong, J. Cogan, Yingping Hou, R. Antaya, Michelle Hao, Gene H. Kim, Vadim Lincoln, Qiuyang Chen, D. Woodley, Mei Chen   +9 more
semanticscholar   +1 more source

Laminin-332 mediates proliferation, apoptosis, invasion, migration and epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma

Molecular Medicine Reports, 2020
The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is primarily due to the invasive and metastatic behaviors of this disease. Laminin-332 (LM-332) is a key component of the basement membrane barrier, and is associated with tumor ...
Caiqun Huang, Jun Chen
semanticscholar   +1 more source