Results 131 to 140 of about 303,757 (355)

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

open access: yesAdvanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao   +16 more
wiley   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee   +5 more
wiley   +1 more source

Transfer Learning Empowered Multiple‐Indicator Optimization Design for Terahertz Quasi‐Bound State in the Continuum Biosensors

open access: yesAdvanced Science, EarlyView.
This study proposes a pioneering method leveraging transfer learning to optimize multiple indicators in meta‐biosensor design, achieving the multiple‐indicator comprehensive optimization. By adopting frequency shift as a unified criterion, this study quantifies the contribution ratio of each performance indicator to the biosensor, which facilitates ...
Shengfeng Wang   +6 more
wiley   +1 more source

Readily Tunable Surface Potential by Functionalizing Pentacene with Dipole Monolayers

open access: yesAdvanced Electronic Materials, EarlyView.
Recently developed chemistry allows monolayers to be generated on the top surface of organic semiconductors. The inherent functional groups and their associated dipole can tune the surface potential by up to 800 mV. Abstract The surface potential of a prototypical organic semiconductor, pentacene, is chemically modified by the addition of a dipole ...
Matthew C. Williams   +4 more
wiley   +1 more source

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

open access: yesThe Lancet, 2017
Simon Iain Hay   +499 more
semanticscholar   +1 more source

Micro‐Engraving UV‐Sensitive Thin‐Film Transistor from Metal–Metal Oxide Nanoparticles with Band‐Gap Engineering

open access: yesAdvanced Electronic Materials, EarlyView.
This study reports the development of UV‐sensitive thin‐film transistors using Ag‐doped ZnO nanoparticles. Through an engraving transfer printing process, high‐resolution patterning of conductive channels achieves feature sizes down to 2 µm. The optimal Ag‐doped ZnO nanoparticles enhance electron mobility and UV responsiveness compared to pristine ZnO ...
U Jeong Yang   +3 more
wiley   +1 more source

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