Results 81 to 90 of about 271,697 (289)

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

333: Central aortic pressure and arterial stiffness as early predictors of gestational hypertension and preeclampsia [PDF]

, 2015
Suwan Mehra, Simarta F. Brennan-Prescod, Jeffrey A. Gavard, Jennifer Goldkamp, Ashraf Mostafa Abd Raboh Mohammed, Collin Miller, Thinh Nguyen, Paul G. Schmitz   +7 more
openalex   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Experiência com marcapasso cardíaco provisório 333 casos

Journal of Cardiac Arrhythmias, 1990
É relatada a experiência com 333 pacientes (pts) submetidos a implante de eletrodo provisório de marcapasso (MPP) no período de maio de 1985 a abril de 1987 ..
JOSÉ LUIZ VERDE DOS SANTOS, DOMINGO MARCOLINO BRAILE, ROBERTO VITO ARDITO, OSWALDO TADEU GRECO, ADALBERTO MENEZES LORGA   +4 more
doaj   +2 more sources

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Viral load dependent cellular heterogeneity in Trichomonas vaginalis at the single cell level

iScience
Summary: Trichomonasvirus (TVV) is a double-stranded RNA virus that persistently infects Trichomonas vaginalis, a protozoan parasite responsible for the most common non-viral sexually transmitted infection.
Hong-Wei Luo, Seow-Chin Ong, Jhen-Wei Syu, Chih-Yu Tsai, Po-Jung Huang, Chi-Ching Lee, Yuan-Ming Yeh, Rose Lin, Cheng-Hsun Chiu, Petrus Tang   +9 more
doaj   +1 more source

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

, 2021
Erik Pettersson, Paul Lichtenstein, Henrik Larsson, Jie Song, Arpana Agrawal, Anders D. Børglum, Cynthia M. Bulik, Mark J. Daly, L.K. Davis, Ditte Demontis, H.J. Edenberg, Jakob Grove, Joel Gelernter, Benjamin M. Neale, Antonio F. Pardiñas, Eli A. Stahl, James Walters, Raymond K. Walters, P.F. Sullivan, Daniëlle Posthuma, Tinca J. C. Polderman   +20 more
openalex   +2 more sources

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Endocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study

Toxics
Background: Endocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.
Feng-Chieh Su, Yi-Chia Wei, Chiao-Yin Sun, Heng-Jung Hsu, Chin-Chan Lee, Yih-Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Yun-An Liu, Chun-Yu Chen   +9 more
doaj   +1 more source