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Challenges and Opportunities in Multi‐Method Integrated Geophysical Prospection of Buried Building Remains at the Sanctuary of Olympia

Archaeological Prospection, EarlyView.
ABSTRACT Ancient Olympia was one of the most important sanctuaries and the venue for the Olympic Games in Greek and Roman times. Its remains are located in the Olympia Terrace (Peloponnese, Greece) at the present‐day confluence of the rivers Alpheios and Kladeos at the base of Mount Kronos.
Sarah Bäumler +10 more
wiley +1 more source

Excellent Outcomes and High Rates of Return to Duty but a 10% Chance of Tear Progression Are Seen Following Arthroscopic Debridement Alongside Adjunctive Procedures for Articular‐Sided, Partial‐Thickness Supraspinatus Tears (Ellman Grade I) in Active‐Duty Service Members Younger Than 50 Years

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate clinical outcomes and return‐to‐duty rates in active‐duty service members younger than 50 years after arthroscopic debridement of Ellman grade I, articular‐sided partial‐thickness rotator cuff tears (PT‐RCTs) of the supraspinatus.
Brian Skura +8 more
wiley +1 more source

Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg +2 more
wiley +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić +4 more
wiley +1 more source

A contribution to the knowledge of Braconinae (Hymenoptera: Braconidae) in some parts of northern and southern Iran

Journal of Crop Protection, 2014
The fauna of the braconid genera Atanycolus Foerster, Glyptomorpha Holmgren, Pseudovipio Szepligeti and Vipio Latreille belonging to the subfamily Braconinae were studied in some parts of northern (Alborz, Qazvin, Gilan and Tehran) and southern provinces
Mohammad Zargar +4 more
doaj

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad +4 more
wiley +1 more source

Effect of melatonin on the contents of fatty acids and antioxidants of saffron

Heliyon
Early leaf senescence at the end of the growing season poses a significant challenge in saffron cultivation. While changes in leaf composition during senescence have been extensively documented in various plants, similar studies on saffron remain ...
Mohammad Mehdi Samim +3 more
doaj +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar +6 more
wiley +1 more source

Risk of venous thromboembolism after SARS‐CoV‐2 vaccination—Evidence from genome‐wide association study and population‐based observational study

British Journal of Clinical Pharmacology, EarlyView.
Aim We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS‐CoV‐2 vaccines. Methods We conducted a genome‐wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS‐CoV‐2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish ...
Sofia Attelind +7 more
wiley +1 more source

Population pharmacokinetics and pharmacodynamics of canagliflozin in paediatric patients with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts +6 more
wiley +1 more source

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