Results 231 to 240 of about 345,256 (321)

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

open access: yesAdvanced Science, EarlyView.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen   +6 more
wiley   +1 more source

The expression and significance of long noncoding RNA XIST/microRNA-340-5p axis and metabolic reprogramming biomarkers in acute cerebrovascular stroke patients: A cross-sectional study. [PDF]

open access: yesMedicine (Baltimore)
Elhorany M   +9 more
europepmc   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai   +12 more
wiley   +1 more source

Surface Engineering Enabled Capacitive Gas‐Phase Water Molecule Sensors in Carbon Nanodots

open access: yesAdvanced Science, EarlyView.
A surface engineering strategy is developed to tune the molecular affinity of carbon nanodots (CDs), leading to capacitive sensors with an impressive detection range from 11% to 98% relative humidity (RH). These sensors demonstrate high sensitivity, with 3.3 × 105 pF/RH, and an exceptional response of 1.8 × 108 % at 98% RH.
Jin‐Xu Qin   +11 more
wiley   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang   +8 more
wiley   +1 more source

Characteristics and long-term health outcomes of the first domestic COVID-19 outbreak cases in Da Nang, Vietnam: a longitudinal cohort study. [PDF]

open access: yesTrop Med Health
Tsuruoka M   +11 more
europepmc   +1 more source

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