Results 21 to 30 of about 366,702 (296)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Planning, designing and construction of series of check dams for soil and water conservation in micro-watershed

Journal of Agrometeorology, 2008
Planning, design and construction parameters of series of water harvesting structures were presented for 66.75 hectares in micro-watershed. Thematic maps were prepared for planning, design of various types of water harvesting structures in 1:5,000 scale
D. T. MESHRAM, V. V. APPA RAO, A. K. SINGH, B. G. BAGLE, D. G. DHANDHAR   +4 more
doaj   +1 more source

Pelvic fixation in surgical correction of neuromuscular scoliosis

North American Spine Society Journal, 2022
Background: Surgical correction of neuromuscular scoliosis can be associated with high complication rates, including such associated with pelvic fixation. Up to now it is debated whether and when to include the pelvis into the fusion construct. Therefore,
Mazda Farshad, Sabrina Weber, José Miguel Spirig, Michael Betz, Samuel Haupt   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

ASEAN Enlargement and Norm Change – A Window of Opportunity for Democracy and Human Rights Entrepreneurs?

Journal of Current Southeast Asian Affairs, 2014
This paper discusses the accession of Myanmar to ASEAN and its effects on the emergence of fundamental political norms in ASEAN. The article first advances the theoretical idea of how accession demands towards Regional Organizations (ROs) open windows of
Kerstin Radtke
doaj  

Isolation and Identification of Culturable Fungal Species Associated with Disease in Vachellia tortilis in Namibia

Journal of Pure and Applied Microbiology, 2017
Vachellia tortilis is a tree belonging to the family Fabaceae that inhabits high temperature and dry environments of the world. It is ecologically and economically significant amongst others of the genera Vachellia and Senegalia.
B. McBenedict, D. Haiyambo, P. Chimwamurombe, I. Mapaure, P. B. Nuuyoma   +4 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Ruling Against the Executive in Amparo Cases: Evidence from the Peruvian Constitutional Tribunal Fallando en Contra del Ejecutivo en los Casos de Amparo: Evidencia del Tribunal Constitucional Peruano

Journal of Politics in Latin America, 2011
In this paper, we systematically analyze decisions made by the Peruvian Constitutional Tribunal from 1996 to 2006 in amparo cases, which significantly impact individual rights.
Lydia Brashear Tiede, Aldo Fernando Ponce   +1 more
doaj