Results 51 to 60 of about 4,432,640 (292)

The emergency department evaluation and outcomes of elderly fallers [PDF]

, 2016
BACKGROUND: Approximately one-third of community dwelling elderly people (age ≥65 years) falls each year contributing to over 2 million elderly emergency department (ED) visits for falls annually.
Tirrell, Gregory
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

XMM-Newton observations of GB B1428+4217: confirmation of intrinsic soft X-ray absorption [PDF]

, 2004
We report the results of XMM-Newton observations of the X-ray bright, radio-loud blazar GB B1428+4217 at a redshift of z=4.72. We confirm the presence of soft X-ray spectral flattening at energies
A. C. Fabian, A. Celotti, Arnaud, Boller, Cappi, Crenshaw, Ehle, Elvis, Fabian, Fabian, Fabian, Fabian, Fabian, Ferland, Ferrero, Fiore, Fiore, Grupe, Hook, K. Iwasawa, M. A. Worsley, O'Flaherty, Péroux, Reeves, Reynolds, Sikora, Worsley, Yuan, Zwaan   +28 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A multi-fin normally-off β-Ga2O3 vertical transistor with a breakdown voltage exceeding 10 kV

Applied Physics Express
We demonstrated a multi-fin normally-off β -Ga _2 O _3 vertical transistor with a breakdown voltage exceeding 10 kV, a specific on-resistance of 289 mΩ·cm ^2 , and a power figure-of-merit of 0.35 GW cm ^−2 .
Daiki Wakimoto, Chia-Hung Lin, Kentaro Ema, Yuki Ueda, Hironobu Miyamoto, Kohei Sasaki, Akito Kuramata   +6 more
doaj   +1 more source

Automation of multiplex biochemical assays to enhance productivity and reduce cycle time using a modular robotic platform

SLAS Technology
Pharmaceutical and biotechnology companies are increasingly being challenged to shorten the cycle time between design, make, test, and analyze (DMTA) compounds.
Buyun Tang, Becky Lam, Stephanie Holley, Martha Torres, Theresa Kuntzweiler, Tatiana Gladysheva, Paul Lang   +6 more
doaj   +1 more source

N-acetylglucosamine suppresses osteoclastogenesis in part through the promotion of O-GlcNAcylation

Bone Reports, 2016
Osteoclasts are the only cells in an organism capable of resorbing bone. These cells differentiate from monocyte/macrophage lineage cells upon stimulation by receptor activator of NF-κB ligand (RANKL).
Tomoharu Takeuchi, Moyuko Nagasaka, Miyuki Shimizu, Mayumi Tamura, Yoichiro Arata   +4 more
doaj   +1 more source

Nonlinear stability of liquid flow down an inclined plan [PDF]

, 2012
A modified energy method is proposed to study the nonlinear stability of Poiseuille flow with upper free boundary St, down an inclined plane. Sufficient conditions on Reynolds, and Weber numbers, on the slope of the plane, together with the periodicity ...
Padula, Mariarosaria
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source