Results 21 to 30 of about 476,155 (267)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

¿Cómo innovan las fintech peruanas? Una aproximación a partir de un estudio de casos múltiple

360, 2019
Las fintech son un tipo de startup con un modelo de negocio disruptivo que brinda servicios financieros digitales. Una de sus principales ventajas competitivas es que innovan continuamente, por lo cual la gestión de la innovación resulta relevante.
Gianella Judith Palomino Barchi, Vanessa Velásquez, Katharine Cledia Marcos Quispe, Jean Pierre Seclen Luna   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Incremental financial costs of strengthening large-scale child nutrition programs in Bangladesh, Ethiopia, and Vietnam: retrospective expenditure analysis

Globalization and Health
Background Inattention to young child growth and development in a transitioning global environment can undermine the foundation of human capital and future progress.
Tina G. Sanghvi, Rick Homan, Tuan Nguyen, Zeba Mahmud, Tamirat Walissa, Marina Nersesyan, Patricia Preware, Edward A. Frongillo, Roger Matheson   +8 more
doaj   +1 more source

Impacto de la vigilancia tecnológica en las pymes de la industria alimentaria

360
Las pequeñas y medianas empresas (pymes) de la industria alimentaria de la zona metropolitana del valle de México (ZMVM) utilizan la vigilancia tecnológica para la recopilación y análisis sistemático de información de diversas fuentes,
Araceli Olivia Mejía Chávez, José Luis Solleiro Rebolledo   +1 more
doaj   +1 more source

Middle class vulnerability to covid-19 pandemic effects and government measures in Metropolitan Lima

360, 2021
Using National Household Survey data, this study examines the situation of Peruvian middle class households in Metropolitan Lima and Callao prior to the COVID-19 pandemic through financial and non-financial variables in order to identify vulnerability ...
Hans Adrian Bürkli Bürkli, Jorge Hernández Garavito, Diego Alberto Mendoza García, Franco Alberto Riva Zaferson   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pursuing Centralization amidst Decentralization: The Politics of Brazil’s Innovative Response to HIV/AIDS Centralizando en un contexto de descentralización: La política de la innovadora respuesta de Brasil al SIDA

Journal of Politics in Latin America, 2011
In recent years, Brazil has been highly revered for its response to HIV/AIDS. Despite the government’s delayed response, why and how did the national AIDS program eventually become so successful?
Eduardo Jesus Gómez
doaj  

Un modelo de gestión de la transformación digital para la innovación

360
La transformación digital está impulsada por el uso de nuevas tecnologías digitales, las cuales están impactando fuertemente en las cadenas de valor, las formas de organización y producción, los canales de distribución, los modelos de negocio y ...
Enrique Alberto Medellín Cabrera
doaj   +1 more source

360 Quantified Self

CoRR, 2015
Wearable devices with a wide range of sensors have contributed to the rise of the Quantified Self movement, where individuals log everything ranging from the number of steps they have taken, to their heart rate, to their sleeping patterns. Sensors do not, however, typically sense the social and ambient environment of the users, such as general life ...
Haddadi, H, Ofli, F, Mejova, Y, Weber, I, Srivastava, J   +4 more
openaire   +2 more sources