Results 81 to 90 of about 5,321,227 (264)

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Moisture and density (MAD) measured on IODP Hole 370-C0023A

, 2018
Moisture and density (MAD) measured on IODP Hole 370 ...
Verena B Heuer (6960776), Yuki Morono (6969194), Expedition 370 Scientists, Lena Maeda (5927063), Expedition 370 Scientists (6969200), Maeda, Lena, Heuer, Verena B, Inagaki, F, Y Kubo (6969197), Kubo, Y, F Inagaki (6969191), Morono, Yuki   +11 more
core   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation

Angewandte Chemie, EarlyView.
A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto, Yusei Otsuka, Asuka Mori, Yuichiro Hori, Yuma Yamamoto, Motonari Uesugi, Kazuya Kikuchi   +6 more
wiley   +2 more sources

Self-management and related factors in patients with systemic lupus erythematosus: a cross-sectional study

Frontiers in Medicine
ObjectiveTo assess the self-management status of patients with SLE and identify the factors that influence it.BackgroundSystemic lupus erythematosus (SLE) is a chronic, relapsing autoimmune disease that requires lifelong management.
Wei Xu, Yan Chen, Xueying Shang, Yan Zhao, Jingru Liu, Jun Li, Bei Zhang, Ping Wang, Ping Wang, Xin Lu   +9 more
doaj   +1 more source

Xray-ct-scanner images from IODP Hole 370-C0023A

, 2018
Xray-ct-scanner images from IODP Hole 370 ...
Verena B Heuer (6960776), Yuki Morono (6969194), Expedition 370 Scientists, Lena Maeda (5927063), Expedition 370 Scientists (6969200), Maeda, Lena, Heuer, Verena B, Inagaki, F, Y Kubo (6969197), Kubo, Y, F Inagaki (6969191), Morono, Yuki   +11 more
core   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Interaction Between PHF8 and a Segment of KDM2A, Which Is Controlled by the Phosphorylation Status at a Specific Serine in an Intrinsically Disordered Region of KDM2A, Regulates rRNA Transcription and Cell Proliferation in a Breast Cancer Cell Line

Biomolecules
Mild starvation due to low concentrations of an inhibitor of glycolysis, 2-deoxy-D-glucose, activates AMP-activated protein kinase (AMPK) and lysine-specific demethylase 2A (KDM2A) to reduce rRNA transcription and cell proliferation in breast cancer ...
Kengo Okamoto, Yutaro Mihara, Sachiko Ogasawara, Takashi Murakami, Sinya Ohmori, Tetsuya Mori, Toshiyuki Umata, Yuki Kawasaki, Kazuya Hirano, Hirohisa Yano, Makoto Tsuneoka   +10 more
doaj   +1 more source

INFLUENCE OF EDUCATIONAL TRAJECTORIES ON THE FORMATION OF THE MANAGERIAL ELITE IN THE RUSSIAN FEDERAL AUTHORITIES

Вестник университета, 2019
The analysis of features of educational trajectories of representatives of Federal managerial elite of Russia has been carried out and their specificity has been defined.
N. A. Yushkina
doaj   +1 more source

Correlation between private education costs and parental depression in South Korea

BMC Public Health, 2020
Background In Korea, higher education has rapidly grown influenced by sociocultural tradition. Parents invest a significant portion of their household income in their children’s education. Private education has been considered to greatly affect students’
Byeong Cheol Oh, Ji-Yoon Yeon, Hyo-Sang Lee, Doo Woong Lee, Eun-Cheol Park   +4 more
doaj   +1 more source