Results 71 to 80 of about 1,390,247 (199)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Critical exponents of finite temperature chiral phase transition in soft-wall AdS/QCD models

Journal of High Energy Physics, 2019
Criticality of chiral phase transition at finite temperature is investigated in a soft-wall AdS/QCD model, with two, three degenerate flavors (N f = 2, 3) and two light plus one heavier flavor (N f = 2 + 1).
Jianwei Chen, Song He, Mei Huang, Danning Li   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The fermion–boson map for large d

Nuclear Physics B, 2019
We show that the three-dimensional map between fermions and bosons at finite temperature generalises for all odd dimensions d>3. We further argue that such a map has a nontrivial large d limit.
Evangelos G. Filothodoros, Anastasios C. Petkou, Nicholas D. Vlachos   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

d-magnetism instability in R-Co intermetallic compounds

Journal of Science: Advanced Materials and Devices, 2016
Magnetic phenomena observed in R-Co intermetallic compounds with the d-magnetism instability are reviewed. The magnetic instability in these compounds is intimately related to the special position of the Fermi level in the hybridized 3d-5d (4d) band near
Irina Yu. Gaidukova, Ashot S. Markosyan
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

3d-3d correspondence and 2d $$\mathcal{N}$$ = (0, 2) boundary conditions

Journal of High Energy Physics
We consider quiver forms that appear in the motivic Donaldson-Thomas generating series or characters of conformal field theories and relate them to 3d $$\mathcal{N}$$ = 2 theories on D 2 × q S 1 with certain boundary conditions preserving 2d $$\mathcal{N}
Hee-Joong Chung
doaj   +1 more source

Anisotropic swim stress in active matter with nematic order

New Journal of Physics, 2018
Active Brownian particles (ABPs) transmit a swim pressure ${{\rm{\Pi }}}^{{\rm{swim}}}=n\zeta {D}^{{\rm{swim}}}$ to the container boundaries, where ζ is the drag coefficient, D ^swim is the swim diffusivity and n is the uniform bulk number density far ...
Wen Yan, John F Brady
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source