Results 61 to 70 of about 571,399 (301)

APPLYING VERSIONING TO MULTI-LOD 3D CITY MODELS

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2022
Abstract. Level of Detail (LoD) is a well known concept in 3D city models, used to designate different geometric detail that can be used in different applications. Nevertheless, multi-LoD datasets are hard to maintain and manage because of their intrinsic complexity.
Vitalis, S., Arroyo Ohori, K., Stoter, J.   +2 more
openaire   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transformation of 3D geospatial data into CityGML – a case of Prague

Reports on Geodesy and Geoinformatics, 2019
The 3D geoinformation is becoming important for cities and their policies. The cities are therefore exploring the possibilities of 3D virtual city models for more efficient decision making.
Janečka Karel
doaj   +1 more source

GENERATING, STORING, UPDATING AND DISSEMINATING A COUNTRYWIDE 3D MODEL [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2020
As in many countries, in The Netherlands governmental organisations are acquiring 3D city models to support their public tasks. However, this is still being done within individual organisation, resulting in differences in 3D city models within one ...
B. Dukai, R. Peters, T. Wu, T. Commandeur, H. Ledoux, T. Baving, M. Post, V. van Altena, W. van Hinsbergh, J. Stoter, J. Stoter   +10 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Assessment and the Future Development of the Zagreb 3D City Model

Tehnički Glasnik
The first 3D model of the city of Zagreb was developed in 2008. Since then, the model has been improved and updated. Today, it is used for various purposes in the city planning and management.
Vlado Cetl, Darko Šiško, Hrvoje Matijević, Danko Markovinović   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Large-Scale LoD2 Building Modeling using Deep Multimodal Feature Fusion

Canadian Journal of Remote Sensing, 2023
In today’s rapidly urbanizing world, accurate 3D city models are crucial for sustainable urban management. The existing technology for 3D city modeling still relies on an extensive amount of manual work and the provided solutions may vary depending on ...
Faezeh Soleimani Vostikolaei, Shabnam Jabari   +1 more
doaj   +1 more source

An overview of virtual city modelling : emerging organisational issues [PDF]

, 2007
This paper presents a recent overview of the increasing use of Virtual Reality (VR) technologies for the simulation of urban environments. It builds on previous research conducted on the identification of three-dimensional (3D) city models and offers an ...
Horne, Margaret, Podevyn, Martin, Thompson, Emine Mine   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source