Results 211 to 220 of about 1,627,552 (307)

Machine learning predictors of post‐radiotherapy cardiotoxicity in a Latin American breast cancer cohort: Clinical risk factors outperform cardiac dosimetry

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Most evidence on post‐radiotherapy cardiotoxicity (CDT) derives from Global North cohorts, and the relative contribution of baseline clinical risk versus cardiac dosimetry remains poorly characterized in Latin American populations.
Víctor Aguirre‐Bravo   +7 more
wiley   +1 more source

Cardiovascular Adaptation in Normal Pregnancy With 2D and 3D Echocardiography, Speckle Tracking, and Radial Artery Tonometry. [PDF]

open access: yesJACC Adv
Naqvi TZ   +9 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, Volume 13, Issue 60, 28 October 2026.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

A Combination of Alleles in LMOD2 and a lncRNA is Strongly Associated With Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels

open access: yesAnimal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT A previous genome‐wide association study identified regions on canine chromosome (cfa) 13 and 14 associated with early onset myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCS). In the present study, whole genome sequencing (WGS) of 9 CKCS cases (mitral regurgitation (MR) before 4.5 years or congestive heart failure
Lisbeth Høier Olsen   +12 more
wiley   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

open access: yesAnimal Models and Experimental Medicine, Volume 9, Issue 10, Page 1913-1927, October 2026.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen   +7 more
wiley   +1 more source

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