Results 51 to 60 of about 1,627,552 (307)

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Reproducibility of parameters assessing right ventricular systolic function in patients after an acute myocardial infarction

Romanian Journal of Internal Medicine
To assess reproducibility of 2D echocardiography parameters of right ventricular systolic function, such as tricuspid annular plane systolic excursion, right ventricular systolic wave velocity, fractional area change, and 3D right ventricular ejection ...
Bratu Vladimir, Copciag Ruxandra, Rimbas Roxana, Vinereanu Dragos   +3 more
doaj   +1 more source

Mitral Paravalvular Leak 3D Printing from 3D-Transesophageal Echocardiography

Anatolian Journal of Cardiology, 2023
Background: Paravalvular leaks can be detected in almost 15% of patients after mitral valve prosthesis implantation. This complication can result in congestive heart failure and hemolysis.
Marek Jedrzejek, Michal Kozlowski, Ewa Peszek-przybyla, Tomasz Jadczyk, Piotr Pysz, Wojciech Wojakowski, Grzegorz Smolka   +6 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Manual of 3D Echocardiography [PDF]

, 2013
* Real-Time Three-Dimensional Echocardiography * How to Perform the 3D Echocardiography * Three-Dimensional Echocardiographic Evaluation of Patients with Rheumatic Mitral Stenosis * Three-Dimensional Echocardiography in Mitral Valve Regurgitation * Three-Dimensional Echocardiography in Aortic and Tricuspid Valve Disease * Three-Dimensional ...
openaire   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Computer-based training in two-dimensional echocardiography using an echocardiography simulator

, 2022
S.362-366Two-dimensional (2D) echocardiography is a user-dependant technique that poses some inherent problems to the beginner. The first problem for beginners is spatial orientation, especially the orientation of the scan plane in reference to the 3 ...
Kreutter, S., Wild, F., Grunst, G., Muth, G., Weidenbach, M., Scheer, K., Berlage, T., Schneider, P.   +7 more
core   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

An Overview for Echocardiography Techniques-An Updated Review for Modern and Advanced Techniques and Innovations [PDF]

Journal of Medical and Life Science
Background: Echocardiography has evolved significantly since its inception in the 18th century, with foundational contributions from Lazzaro Spallanzani and practical applications pioneered by Hertz and Edler in 1954. Initially reliant on M-mode imaging,
Abdul Mohsen Al-Assaf, Turki Al-Harbi, Hajed Al-Mutairi, Badr Ayed, Mohammed Al-Sharif, Ibrahim Al-Qarni, Saleh Al-Ghashem, Awaid Al-Mutairi, Asim Malibari, Salma Alshammari   +9 more
doaj   +1 more source