Results 101 to 110 of about 1,477,728 (279)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Photometric Stereo Using Re-Projected Images for Active Stereo Vision System

Applied Sciences, 2017
In optical 3D shape measurement, stereo vision with structured light can measure 3D scan data with high accuracy and is used in many applications, but fine surface detail is difficult to obtain.
Keonhwa Jung, Seokjung Kim, Sungbin Im, Taehwan Choi, Minho Chang   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A RE-Based Double Measurement Method for Unknown Rotor Profile of Screw Compressor

Advances in Mechanical Engineering, 2014
An accurate and efficient measurement for unknown rotor profile of screw compressor has been a nodus in the field of coordinate measuring machine (CMM) measurement because of its complexity of 3D helical surface, whose normal vectors vary with different ...
Xiao-Gang Ji, Yan Yang, Jie Xue, Xue-Ming He   +3 more
doaj   +1 more source

The registration of point cloud data from range imaging camera

Geodesy and Cartography, 2013
The measurement and 3D modelling techniques have been evolved as parallel technological improvements. Every new technique provides an opportunity for low-cost and fast measurements.
Cihan Altuntas, Ferruh Yildiz
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

3D Wide FOV Scanning Measurement System Based on Multiline Structured-Light Sensors

Advances in Mechanical Engineering, 2014
Structured-light three-dimensional (3D) vision measurement is currently one of the most common approaches to obtain 3D surface data. However, the existing structured-light scanning measurement systems are primarily constructed on the basis of single ...
He Gao, Fuqiang Zhou, Bin Peng, Yexin Wang, Haishu Tan   +4 more
doaj   +1 more source

Three-dimensional shape measurement of a transparent object using a rangefinding approach [PDF]

, 2003
This paper describes a non-contact optical measuring approach by which to measure the three-dimensional (3D) shape of a transparent object such as a glass panel or an acrylic plate.
Baba, Mitsuru, Narita, Daisuke, Ohtani, Kozo   +2 more
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