Results 101 to 110 of about 3,343,678 (291)
Design and practice of coal mine geological emergency rescue information system
Meikuang AnquanWith the large-scale mining of coal resources, there are more and more potential hazards of coal mine geological disasters. Coal mine disaster accidents often have the characteristics of suddenness, contingency and complex.
Yongpeng YU +6 more
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The laser scanning in the digitization process of relictually preserved architectural details
Technical Transactions, 2017 Protection of cultural heritage in recent times is of a very important significance. The priority task is to secure the existing facilities in such a way that they can now and in the future serve as a representations of the areas and be a treasure house ...
Łukaszewski Łukasz
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Hohensalzburg Digital: Engaging the Public via a Local Time Machine Project
Open ArchaeologyHohensalzburg Digital is a Digital Humanities project realized at Salzburg University and dedicated to digitally process and connect room- and object-related information taken from written sources and from building history data on Hohensalzburg Castle ...
Antenhofer Christina +3 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Open Reading Frame 4 protein as potential drug target for HEV: Structural evaluation through computational approaches [PDF]
Network BiologyHepatitis E virus (HEV) is the main cause of acute hepatitis worldwide. The viral infection caused by G1 HEV in pregnant women has become a major health concern in the past few years. The mechanism underlying the pathogenesis of viral infection in HEV G1
Zoya Shafat, Shama Parveen
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Excavations at Aberdeen's Carmelite Friary, 1980-1994
Internet Archaeology, 2019 This is a report on two excavations at the Carmelite friary in an area of Aberdeen called the Green. The 1980-1 excavation revealed the south-west corner of the church and the south end of what was probably the west range of the friary.
Alison Cameron +2 more
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Computer simulation of facial individual implants
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The possibilities of the spiral computed tomography to eliminate post-traumatic defects and deformations of the linear and geometric parameters of individual implants are studied. Set of criteria for assessing the orbital data is determined.
A. N. Dudzich +5 more
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