Results 251 to 260 of about 1,562,489 (318)

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™). [PDF]

Clin Pharmacol Ther
Chothe PP, Whitcher-Johnstone A, Karve A, Ramsden D, Hariparsad N.   +4 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Development and Validation of a Flow-Dependent Endothelialized 3D Model of Intracranial Atherosclerotic Disease. [PDF]

Transl Stroke Res
Prochilo G, Li C, Miliotou E, Nakasone R, Pfeffer A, Beaman C, Kaneko N, Liebeskind DS, Hinman JD.   +8 more
europepmc   +1 more source

3D model

, 2007
E de Kemp, M R St-Onge
openaire   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy-Associated S. aureus Challenge. [PDF]

Allergy
Brzoza P, Camacho M, Tyshchenko M, Morytko A, Kwitniewski M, Pastuszczak M, Stepinska P, Migaczewski M, Cichy J.   +8 more
europepmc   +1 more source

An interdisciplinary approach in teaching RNA secondary structure prediction to first-year undergraduate students using an automated deep learning RNA 3D model prediction tool. [PDF]

J Microbiol Biol Educ
Bhattacharjee K, Idris A.
europepmc   +1 more source

Triangular fossa of the third cerebral ventricle - an original 3D model and morphometric study. [PDF]

Front Neuroanat
Nedelcu AH, Lupu VV, Lupu A, Tepordei RT, Ioniuc I, Stan CI, Vicoleanu SAP, Haliciu AM, Statescu G, Ursaru M, Danielescu C, Tarniceriu CC.   +11 more
europepmc   +1 more source

Multicellular ovarian cancer spheroids: novel 3D model to mimic tumour complexity. [PDF]

Sci Rep
Flörkemeier I, Antons LK, Weimer JP, Hedemann N, Rogmans C, Krüger S, Scherließ R, Dempfle A, Arnold N, Maass N, Bauerschlag DO.   +10 more
europepmc   +1 more source

Mesenchymal Stem Cells-Derived Small Extracellular Vesicles and Their Validation as a Promising Treatment for Chondrosarcoma in a 3D Model in Vitro. [PDF]

Biotechnol Bioeng
Romano E, Perut F, Avnet S, Di Pompo G, Silvestri S, Roffo F, Baldini N, Netti PA, Torino E.   +8 more
europepmc   +1 more source