Results 71 to 80 of about 3,343,678 (291)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Invariant Gibbs measures of the energy for shell models of turbulence; the inviscid and viscous cases

open access: yes, 2011
Gaussian measures of Gibbsian type are associated with some shell models of 3D turbulence; they are constructed by means of the energy, a conserved quantity for the 3D inviscid and unforced shell model.
Bessaih, Hakima, Ferrario, Benedetta
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Multiscaling in superfluid turbulence: A shell-model study

open access: yes, 2015
We examine the multiscaling behavior of the normal- and superfluid-velocity structure functions in three-dimensional superfluid turbulence by using a shell model for the three-dimensional (3D) Hall-Vinen-Bekharevich-Khalatnikov (HVBK) equations.
Pandit, Rahul, Shukla, Vishwanath
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The formation of IRIS diagnostics I. A quintessential model atom of Mg II and general formation properties of the Mg II h&k lines

open access: yes, 2013
NASA's Interface Region Imaging Spectrograph (IRIS) space mission will study how the solar atmosphere is energized. IRIS contains an imaging spectrograph that covers the Mg II h&k lines as well as a slit-jaw imager centered at Mg II k.
Carlsson, M.   +4 more
core   +1 more source

3D modeling with silhouettes

open access: yesACM Transactions on Graphics, 2010
We present a new sketch-based modeling approach in which models are interactively designed by drawing their 2D silhouettes from different views. The core idea of our paper is to limit the input to 2D silhouettes, removing the need to explicitly create or position 3D elements. Arbitrarily complex models can be constructed by assembling them out of parts
Rivers, Alec Rothmyer   +2 more
openaire   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Impact of granulation effects on the use of Balmer lines as temperature indicators

open access: yes, 2009
Balmer lines serve as important indicators of stellar effective temperatures in late-type stellar spectra. One of their modelling uncertainties is the influence of convective flows on their shape. We aim to characterize the influence of convection on the
Asplund   +20 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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